|
rs1433372015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
STING N153S mice were highly vulnerable to infection and developed pulmonary fibrosis after infection.
|
30463976 |
2019 |
|
rs587777609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
STING N153S mice were highly vulnerable to infection and developed pulmonary fibrosis after infection.
|
30463976 |
2019 |
|
rs121917737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G231V and F198S mutations in surfactant protein A2 (SP-A2) are associated with familial pulmonary fibrosis.
|
30293573 |
2018 |
|
rs121917738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G231V and F198S mutations in surfactant protein A2 (SP-A2) are associated with familial pulmonary fibrosis.
|
30293573 |
2018 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In subgroup analyses by ethnicity or original disease, no statistically significant association between TGF-β1 rs1800470 polymorphisms and PF was demonstrated.This meta-analysis revealed that TGF-β1 rs1800470 polymorphism was not associated with susceptibility to PF development.
|
30212926 |
2018 |
|
rs2609255
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671).
|
29621588 |
2018 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results also suggested that miR-146a rs2910164 CC genotype may be predisposing factor for development lung fibrosis and more progressive form of SSc.
|
30308218 |
2018 |
|
rs6837671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two recent genome-wide association studies (GWASs) reported that the FAM13A gene at the 4q22 locus associated with pulmonary fibrosis (defined by rs2609255) overlapping with COPD (defined by rs6837671).
|
29621588 |
2018 |
|
rs1022113606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used R213G mice expressing a naturally occurring single-nucleotide polymorphism, rs1799895, within the heparin-binding domain of SOD3, which results in an amino acid substitution at position 213 to test the hypothesis that the redistribution of SOD3 into the extracellular fluids would impart protection against bleomycin-induced lung fibrosis and secondary pulmonary hypertension (PH).
|
27805412 |
2017 |
|
rs1799895
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used R213G mice expressing a naturally occurring single-nucleotide polymorphism, rs1799895, within the heparin-binding domain of SOD3, which results in an amino acid substitution at position 213 to test the hypothesis that the redistribution of SOD3 into the extracellular fluids would impart protection against bleomycin-induced lung fibrosis and secondary pulmonary hypertension (PH).
|
27805412 |
2017 |
|
rs2034650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP in IVD (chromosome15, rs2034650) was significantly associated with pulmonary fibrosis in both the Mexican (OR = 0.40, P = .01) and Korean (OR = 0.13, P = .0008) cohorts.
|
25275363 |
2015 |
|
rs2241718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional polymorphism (Q705K; rs35829419) in the NLRP3 gene was associated with interstitial lung fibrosis (p=0.013), and the TGFB1 rs2241718 SNP with visceral pleural fibrosis (VPF) (p=0.044).
|
24142982 |
2014 |
|
rs35829419
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results support the hypothesis that the NLRP3 inflammasome is important in the development of fibrotic lung disease by associating the NLRP3 rs35829419 variant allele with increased risk of asbestos-related interstitial lung fibrosis, and the TGFB1 rs2241718 variant allele with decreased risk of asbestos-related VPF.
|
24142982 |
2014 |
|
rs10168266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc).
|
23755762 |
2013 |
|
rs34794968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, haplotype block analysis revealed a significant association for the TCG haplotype (SNP order: rs763361, rs34794968, rs727088) with lung fibrosis positive patients (PBonf = 3.18E-02 OR 1.27 (1.05 to 1.54)).
|
22531499 |
2012 |
|
rs727088
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, haplotype block analysis revealed a significant association for the TCG haplotype (SNP order: rs763361, rs34794968, rs727088) with lung fibrosis positive patients (PBonf = 3.18E-02 OR 1.27 (1.05 to 1.54)).
|
22531499 |
2012 |
|
rs141425941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified two pulmonary fibrosis families that share two non-synonymous substitutions in the catalytic domain of the telomerase reverse transcriptase gene hTERT: V791I and V867M.
|
21483807 |
2011 |
|
rs3917200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, there is evidence that rs3917200 is involved in the development of lung </span>fibrosis</span> in sarcoidosis.
|
21148227 |
2011 |
|
rs2276109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MMP-12 rs2276109 gene polymorphism may contribute to susceptibility to SSc, and in particular to dcSSc and pulmonary fibrosis.
|
20595276 |
2010 |
|
rs652438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fibrosis.
|
20392358 |
2010 |
|
rs11575937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A clinical picture related to the LMNA Arg482Gln mutation may be more diversified than it was previously considered and include low BMI and pulmonary fibrosis.
|
19859838 |
2009 |
|
rs1059702
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
|
rs2004640
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
|
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
|
rs1059702
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the other hand, IRAK1 rs1059702 was consistently associated with presence of pulmonary fibrosis (PF), because statistical significance was observed when comparing SSc patients PF+ versus controls (PFDR=0.039, OR=1.30, 95% CI 1.07 to 1.58) and SSc patients PF+ versus SSc patients PF- (p=0.025, OR=1.26, 95% CI 1.03 to 1.55).
|
23444193 |
2013 |