| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.080 | GeneticVariation | BEFREE | Sign of these predictive effects is opposite: subjects with MTHFR 677C>T polymorphism have lower likelihood of renal insufficiency; differently, wild-type MTHFR genotype subjects have lower GFR and greater hsCRP, iPTH, RRI, and LVH. | 23534584 | 2013 |
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0.080 | GeneticVariation | BEFREE | The MTHFR C677T polymorphism plays a significant role in predisposition of renal insufficiency in diabetic patients. | 23846111 | 2013 |
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0.080 | GeneticVariation | BEFREE | Obtained results indicate that C677T polymorphism is not associated with onset, duration and cause of kidney failure in our hemodialysis population. | 20433440 | 2010 |
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0.080 | GeneticVariation | BEFREE | However, we did not prove the hypothesis that MTHFR 677C --> T influences the risk of development of renal failure in the course of hypertension. | 16280279 | 2005 |
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0.080 | GeneticVariation | BEFREE | The methylenetetrahydrofolate reductase 677 C/T genotypes were determined in 174 type 2 diabetic patients: 80 with and 94 without renal failure due to diabetic nephropathy. | 12784186 | 2003 |
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0.080 | GeneticVariation | BEFREE | Homocysteine, folate, vitamin B12 levels, and C677T MTHFR mutation in children with renal failure. | 12644913 | 2003 |
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0.080 | GeneticVariation | BEFREE | While both renal failure and mutations of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene may result in hyperhomocysteinemia and CVD, the distinct roles of the thermolabile MTHFR mutation at nucleotide C677T and the more recently described mutation at nucleotide A1298C have not been evaluated concurrently in patients on hemodialysis. | 12187094 | 2002 |
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0.080 | GeneticVariation | BEFREE | The combined effect of renal failure and a common mutation (C677T) in the methylenetetrahydrofolate reductase gene that leads to serum homocysteine elevations in dialysis patients was investigated. | 10770966 | 2000 |