Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE Sign of these predictive effects is opposite: subjects with MTHFR 677C>T polymorphism have lower likelihood of renal insufficiency; differently, wild-type MTHFR genotype subjects have lower GFR and greater hsCRP, iPTH, RRI, and LVH. 23534584

2013

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE The MTHFR C677T polymorphism plays a significant role in predisposition of renal insufficiency in diabetic patients. 23846111

2013

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE Obtained results indicate that C677T polymorphism is not associated with onset, duration and cause of kidney failure in our hemodialysis population. 20433440

2010

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE However, we did not prove the hypothesis that MTHFR 677C --> T influences the risk of development of renal failure in the course of hypertension. 16280279

2005

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE The methylenetetrahydrofolate reductase 677 C/T genotypes were determined in 174 type 2 diabetic patients: 80 with and 94 without renal failure due to diabetic nephropathy. 12784186

2003

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE Homocysteine, folate, vitamin B12 levels, and C677T MTHFR mutation in children with renal failure. 12644913

2003

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE While both renal failure and mutations of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene may result in hyperhomocysteinemia and CVD, the distinct roles of the thermolabile MTHFR mutation at nucleotide C677T and the more recently described mutation at nucleotide A1298C have not been evaluated concurrently in patients on hemodialysis. 12187094

2002

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE The combined effect of renal failure and a common mutation (C677T) in the methylenetetrahydrofolate reductase gene that leads to serum homocysteine elevations in dialysis patients was investigated. 10770966

2000

dbSNP: rs1801282
rs1801282
0.020 GeneticVariation BEFREE Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001). 25784779

2015

dbSNP: rs1805192
rs1805192
0.020 GeneticVariation BEFREE Cox's proportional hazard regression showed that both Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM (Pro12Ala: GG versus other genotypes, hazard ratio [HR] <0.01; P < 0.001; for C161T, CC versus TT genotypes, HR 2.86; P < 0.001; CT versus TT genotypes, HR 1.93; P < 0.001). 25784779

2015

dbSNP: rs2032487
rs2032487
0.020 GeneticVariation BEFREE MYH9 SNPs rs4821480, rs2032487, rs4281481 and rs3752462 are associated with T2DM-ESRD susceptibility in European Americans. 21968013

2012

dbSNP: rs2032487
rs2032487
0.020 GeneticVariation BEFREE Contrasting the 751 T2DM-ESRD cases with 227 T2DM non-nephropathy controls revealed that E1 haplotype SNPs rs4821480, rs2032487 and rs4821481 were associated with kidney failure (OR 1.38-1.40 recessive, all P < 0.048). 19567477

2009

dbSNP: rs1801282
rs1801282
0.020 GeneticVariation BEFREE The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy. 18467141

2008

dbSNP: rs1805192
rs1805192
0.020 GeneticVariation BEFREE The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy. 18467141

2008

dbSNP: rs367825197
rs367825197
0.010 GeneticVariation BEFREE In the present study, we report the identification of a heterozygous nonsense <i>PODXL</i> mutation (c.C976T; p. Arg326X) in a Chinese pedigree featured by proteinuria and renal insufficiency with AD inheritance by whole exome sequencing (WES). 30523047

2019

dbSNP: rs118203979
rs118203979
0.010 GeneticVariation BEFREE Patients with p.G20D homozygous mutation in CLDN19 gene exhibit different progression to kidney failure suggesting that beyond the pathogenic mutation itself, other molecular events are favoring disease progression. 30305086

2018

dbSNP: rs4362
rs4362
ACE
0.010 GeneticVariation BEFREE Influence of angiotensin converting enzyme (<i>ACE</i>) gene rs4362 polymorphism on the progression of kidney failure in patients with autosomal dominant polycystic kidney disease (ADPKD). 27748299

2016

dbSNP: rs200640958
rs200640958
0.010 GeneticVariation BEFREE Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family. 26147534

2015

dbSNP: rs2285450
rs2285450
0.010 GeneticVariation BEFREE Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family. 26147534

2015

dbSNP: rs437168
rs437168
0.010 GeneticVariation BEFREE Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family. 26147534

2015

dbSNP: rs437168
rs437168
0.010 GeneticVariation BEFREE Two synonymous NPHS1 polymorphisms, rs2285450 (c.294C>T) and rs437168 (c.2289C>T) segregated with renal failure in this family. 26147534

2015

dbSNP: rs734553
rs734553
0.010 GeneticVariation BEFREE The strongest genetic marker of uric acid levels, the rs734553 SNP in the GLUT9 urate transporter gene, predicts progression to kidney failure in CKD patients and associates with systolic BP and carotid intima media thickness in family-based studies. 26607700

2015

dbSNP: rs754919065
rs754919065
0.010 GeneticVariation BEFREE Here, we describe a family where six members had a novel TRPC6 p.R68W (c.202C>T) mutation, two of whom had renal failure from FSGS, and one had proteinuria. 26147534

2015

dbSNP: rs538166970
rs538166970
ACE
0.010 GeneticVariation BEFREE In contrast, another mutant, R1180P, was compatible with life after transient neonatal renal insufficiency. 24163131

2014

dbSNP: rs104886303
rs104886303
0.010 GeneticVariation BEFREE The L1649R mutation in the COL4A5 gene causes a relatively mild form of XLAS characterized by late-onset renal failure and less frequent, severe temporal macular thinning relative to other COL4A5 mutations. 23572034

2013