|
rs11265618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we aimed to investigate the influence of clinical parameters and single-nucleotide polymorphisms of interleukin-6 receptor (rs12083537, rs2228145, rs4329505 and rs11265618) on response to tocilizumab, TCZ (European League Against Rheumatism (EULAR) response, remission, low disease activity (LDA) and improvement of DAS28).
|
27958380 |
2018 |
|
rs11541076
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Primary analyses validated the IRAK3 rs11541076 variant as associated (odds ratio (OR)=1.33, 95% confidence interval (CI): 1.00-1.77, P-value=0.047) with a positive treatment response (EULAR (European League Against Rheumatism) good/moderate vs none response at 4±2 months), and found the NLRP3 rs461266 variant associated (OR=0.75, 95% CI: 0.60-0.94, P=0.014) with a negative treatment response.
|
27698401 |
2018 |
|
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we aimed to investigate the influence of clinical parameters and single-nucleotide polymorphisms of interleukin-6 receptor (rs12083537, rs2228145, rs4329505 and rs11265618) on response to tocilizumab, TCZ (European League Against Rheumatism (EULAR) response, remission, low disease activity (LDA) and improvement of DAS28).
|
27958380 |
2018 |
|
rs4329505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we aimed to investigate the influence of clinical parameters and single-nucleotide polymorphisms of interleukin-6 receptor (rs12083537, rs2228145, rs4329505 and rs11265618) on response to tocilizumab, TCZ (European League Against Rheumatism (EULAR) response, remission, low disease activity (LDA) and improvement of DAS28).
|
27958380 |
2018 |
|
rs461266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Primary analyses validated the IRAK3 rs11541076 variant as associated (odds ratio (OR)=1.33, 95% confidence interval (CI): 1.00-1.77, P-value=0.047) with a positive treatment response (EULAR (European League Against Rheumatism) good/moderate vs none response at 4±2 months), and found the NLRP3 rs461266 variant associated (OR=0.75, 95% CI: 0.60-0.94, P=0.014) with a negative treatment response.
|
27698401 |
2018 |
|
rs2230926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TNFAIP3 (rs2230926) had the strongest effect related to European League Against Rheumatism response.
|
28639493 |
2017 |
|
rs11466657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
I473T variant is not associated with susceptibility to RA, but it significantly correlates with erosive disease in patients seropositive for antibodies to citrullinated protein antigens (p = 0.017 in the total cohort and p = 0.0049 in female patients) and with a lower response to infliximab treatment as measured by the change in Disease Activity Score in 28 joints (p = 0.012) and by the European League Against Rheumatism criteria (p = 0.049).
|
27716427 |
2016 |
|
rs12720270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no associations were found between the rs12720270, rs280500, rs280523 and rs8108236 polymorphisms and susceptibility to rheumatic diseases.
|
26980740 |
2016 |
|
rs12720356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with SLE in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians.
|
26980740 |
2016 |
|
rs2304256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with SLE in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians.
|
26980740 |
2016 |
|
rs280500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no associations were found between the rs12720270, rs280500, rs280523 and rs8108236 polymorphisms and susceptibility to rheumatic diseases.
|
26980740 |
2016 |
|
rs280519
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with SLE in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians.
|
26980740 |
2016 |
|
rs280523
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no associations were found between the rs12720270, rs280500, rs280523 and rs8108236 polymorphisms and susceptibility to rheumatic diseases.
|
26980740 |
2016 |
|
rs8108236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no associations were found between the rs12720270, rs280500, rs280523 and rs8108236 polymorphisms and susceptibility to rheumatic diseases.
|
26980740 |
2016 |
|
rs10903323
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 1302 patients fulfilling the 1987 American College of Rheumatism classification criteria for RA were genotyped for the MSRA rs10903323 (G/A) polymorphism.
|
22657383 |
2012 |
|
rs774359492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the FAS -670 A/G polymorphism confers susceptibility to rheumatic diseases in Asians and SLE and RA, and the FAS -1,377 G/A polymorphism is associated with SLE susceptibility.
|
23053964 |
2012 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C282Y and H63D allele frequencies were 4.5 and 12.8 in patients with rheumatic diseases.
|
15789881 |
2005 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C282Y and H63D allele frequencies were 4.5 and 12.8 in patients with rheumatic diseases.
|
15789881 |
2005 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess potential associations between Korean Behçet's disease (BD) or other rheumatic diseases with vasculitis and two polymorphisms of the endothelial nitric oxide synthase (eNOS) gene, which include the Glu298Asp polymorphism in exon 7 and a variable number of tandem repeats (VNTR) polymorphism in intron 4.
|
14583572 |
2003 |