|
rs1000731
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant relationship between other DISC1 polymorphisms (rs3738401, rs2273890, rs3738398, rs3738402, rs2492367, rs843979, rs3737597, rs4658971, rs1538979, rs1000731 and rs3738399) and SCZ.
|
29031911 |
2018 |
|
rs11122324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two SNPs (rs11122324 and rs2793091) of DISC1 may be specifically associated with multiplex schizophrenia patients with deficient sustained attention.
|
30976040 |
2019 |
|
rs1238276682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the NIMH sibling study (SS), a non-independent case-control set, and an independent German (G) case-control set, we performed conditional/unconditional logistic regression to test for epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes.
|
17006672 |
2007 |
|
rs1322784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, evidence for association to Asperger syndrome was observed with an intragenic single nucleotide polymorphism (SNP) of DISC1 (rs1322784; P=0.0058), as well as with a three-SNP haplotype (P=0.0013) overlapping the HEP3 haplotype, that was previously observed to associate with schizophrenia in Finnish families.
|
17579608 |
2008 |
|
rs1538979
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirm the SNP interplay effect between rs1538979 and rs821633 that significantly conferred disease risk in male patients with schizophrenia (P = 0.016, OR 1.57).
|
19414483 |
2009 |
|
rs1538979
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, there was an effect of SNP rs1538979 in the pre/postcentral gyrus with decreased activation in healthy controls and increased activation in patients with schizophrenia.
|
21376542 |
2011 |
|
rs17817356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs2255340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study was to investigate the association of three single-nucleotide polymorphisms (SNPs; rs6675281, rs2255340, and rs2738864) with schizophrenia disorder.
|
30324622 |
2018 |
|
rs2738864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data revealed that the three SNPs are significantly associated with schizophrenia (rs2255349 C>T: confidence interval (CI), 2.115 to 3.268; P = 0.0000 OR: 2.629; rs2738864 C>T: CI, 1.538 to 2.339; P = 0.0000 OR: 1.897; rs6675281 C>T: CI, 2.788 to 4.662; P = 0.0009241 OR: 3.605).
|
30324622 |
2018 |
|
rs2793091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two SNPs (rs11122324 and rs2793091) of DISC1 may be specifically associated with multiplex schizophrenia patients with deficient sustained attention.
|
30976040 |
2019 |
|
rs2793092
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T/T genotype of rs2793092 SNP in DISC1 was significantly associated with increased LV volume.
|
19913623 |
2010 |
|
rs2812393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two-locus analysis showed C-C (rs766288-rs2812393) as a risk combination in BPAD, and G-T (rs2812393-rs821616) as a protective combination in SCZ and combined cases of BPAD or SCZ.
|
22673686 |
2012 |
|
rs373288445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
D2R-DISC1 complex levels are increased in conjunction with decreased GSK-3α/β (Ser21/9) phosphorylation in both postmortem brain tissue from schizophrenia patients and in Disc1-L100P mutant mice, an animal model with behavioral abnormalities related to schizophrenia.
|
25433637 |
2014 |
|
rs3737597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that rs3737597 of DISC1 was significantly associated with schizophrenia in Europeans, and it can be suggested as an ethnic-specific risk genetic factor.
|
30252773 |
2018 |
|
rs3737597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs3738399
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant relationship between other DISC1 polymorphisms (rs3738401, rs2273890, rs3738398, rs3738402, rs2492367, rs843979, rs3737597, rs4658971, rs1538979, rs1000731 and rs3738399) and SCZ.
|
29031911 |
2018 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The strongest association is with a haplotype of SNPs rs751229 and rs3738401, located at the 5' end of the gene; the C-A haplotype of these SNPs is associated with a relative risk of schizophrenia of 5 in our population.
|
16389590 |
2006 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia.
|
20531374 |
2011 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition, we confirm that two common structural variants (Q264R and S704C) elevate the risk for schizophrenia slightly (odds ratio 1.3, 95% CI: 1.0-1.7).
|
18164685 |
2008 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Both rs3738401 and rs821616 showed not significantly association with schizophrenia in the Caucasian, Asian, Japanese or Han Chinese populations.
|
29410289 |
2018 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To examine any association between DISC1 and SCZ, we genotyped three clinical single nucleotide polymorphisms (SNPs) (rs3738401, R264Q; rs3738402, L465L; rs821616, S704C) in the coding region of the DISC1 gene using the Illumina Sentrix Array Matrix chip and direct sequencing in 303 patients with SCZ and 300 healthy controls.
|
17997036 |
2008 |
|
rs3738402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine any association between DISC1 and SCZ, we genotyped three clinical single nucleotide polymorphisms (SNPs) (rs3738401, R264Q; rs3738402, L465L; rs821616, S704C) in the coding region of the DISC1 gene using the Illumina Sentrix Array Matrix chip and direct sequencing in 303 patients with SCZ and 300 healthy controls.
|
17997036 |
2008 |
|
rs569395146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant relationship was found between the -274G>C, c.791G>A, and c.2110A>T haplotypes and development of different acute symptoms of schizophrenia.
|
23347445 |
2013 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated whether the DISC1 leu607phe polymorphism was associated with prefrontal gray matter volumes using magnetic resonance imaging in a cohort of patients with schizophrenia (N=19) and healthy volunteers (N=25) and positive and negative symptoms in 200 patients with schizophrenia.
|
18078707 |
2008 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia.
|
20531374 |
2011 |