rs10489202
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In the replication analysis, rs10489202 showed marginal association with schizophrenia (two-tailed P = 0.071, OR = 1.192 for T allele); in the meta-analysis using a total of 14,340 cases and 20,349 controls from ten East Asian samples, rs10489202 was genome-wide significantly associated with schizophrenia (two-tailed P = 3.39 × 10<sup>-10</sup>, OR = 1.161 for T allele, under the fixed-effect model).
|
30087317 |
2018 |
rs10489202
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Our case-control study failed to validate the significant association of NKAPL rs1635, TSPAN18 rs11038167, and MPC2 rs10489202 polymorphisms with SZ susceptibility in the southern Zhuang or Han Chinese population.
|
27460766 |
2017 |
rs10489202
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The results showed that rs10489202 in MPC2 (BRP44) is significantly associated with schizophrenia in these East Asian replication samples (one-tailed P=5.75×10(-3), OR=1.12), and further meta-analysis after including previous GWAS data yielded a genome-wide significant association (two-tailed P=1.11×10(-10), OR=1.19), adding further support for the involvement of this locus in the genetic risk of schizophrenia, and future studies regarding the underlying molecular mechanisms of the risk association are necessary.
|
26899211 |
2016 |
rs10489202
|
|
|
0.850 |
GeneticVariation |
BEFREE |
A recent genome-wide association study (GWAS) of Han Chinese identified a single-nucleotide polymorphism (SNP, rs10489202) in the mitochondrial pyruvate carrier 2 gene (MPC2, also known as BRP44) as a possible susceptibility locus for schizophrenia.
|
23933155 |
2013 |
rs10489202
|
|
A |
0.850 |
GeneticVariation |
GWASDB |
Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)).
|
22037555 |
2011 |
rs10489202
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)).
|
22037555 |
2011 |
rs10489202
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)).
|
22037555 |
2011 |