|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
For NRG1 polymorphisms, in the early onset subgroup (≤25years), the rs3924999 G/G genotype was susceptible to schizophrenia</span>.
|
27236031 |
2016 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our study established a significant association of rs35753505 with schizophrenia but no association with rs3924999 and rs2954041.
|
25106628 |
2014 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.
|
23489597 |
2013 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The G/G carriers of rs3924999 tended to perform worse in the P300 latency as compared to A/A or A/G carriers both in the schizophrenia and controls.
|
22467496 |
2012 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These findings indicate that NRG1 rs3924999 affects spatial accuracy on the AS task, suggesting an influence of the gene on the neural mechanisms underlying visuospatial sensorimotor transformations, a mechanism that has been previously found to be impaired in patients with schizophrenia and their relatives.
|
20497232 |
2010 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A missense mutation on rs3924999 of the neuregulin 1 gene may have a functional effect on prepulse inhibition in both schizophrenia and healthy control populations.
|
17631867 |
2008 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
On the basis of the contrast between the findings of other study and our family-based study and the negative findings of our case-control association study, we conclude that NRG1 Arg38Gln polymorphism is not likely to play a major role in the pathogenesis of schizophrenia in Chinese populations.
|
15276238 |
2004 |
|
rs3924999
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography.
|
12874607 |
2003 |