|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Although the conformation of DISC1 partial peptide with the schizophrenia-related mutation L607F in human or the corresponding L604F in mouse was essentially indistinguishable from the wild type (WT) as long as monitored by fluorescence, circular dichroism, ultracentrifugation, dynamic light scattering and nuclear magnetic resonance, the atomic force microscopy was able to detect their morphological distinctions.
|
30561706 |
2019 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our data revealed that the three SNPs are significantly associated with schizophrenia (rs2255349 C>T: confidence interval (CI), 2.115 to 3.268; P = 0.0000 OR: 2.629; rs2738864 C>T: CI, 1.538 to 2.339; P = 0.0000 OR: 1.897; rs6675281 C>T: CI, 2.788 to 4.662; P = 0.0009241 OR: 3.605).
|
30324622 |
2018 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We sought to examine the effects of the DISC1 Leu(607) Phe polymorphism on brain activation in young healthy individuals at familial risk of bipolar disorder (n = 84), in a group of controls (n = 78), and in a group at familial risk of schizophrenia (n = 47), performing a language task.
|
22337479 |
2012 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Three common missense variants of the Disrupted in Schizophrenia 1 (DISC1) gene, rs3738401 (Q264R), rs6675281 (L607F) and rs821616 (S704C), have been variably associated with the risk of schizophrenia.
|
20531374 |
2011 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Schizophrenia risk-associated polymorphisms [non-synonymous SNPs rs821616 (Cys704Ser) and rs6675281 (Leu607Phe), and rs821597] were associated with the expression of Delta3 and Delta7Delta8.
|
19805229 |
2009 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated whether the DISC1 leu607phe polymorphism was associated with prefrontal gray matter volumes using magnetic resonance imaging in a cohort of patients with schizophrenia (N=19) and healthy volunteers (N=25) and positive and negative symptoms in 200 patients with schizophrenia.
|
18078707 |
2008 |