|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, since NRG1 rs6994992 is not a schizophrenia risk variant in the Han Chinese population, the validated association suggested that ethnic difference may exist in the relationship between NRG1 rs6994992, schizophrenia and creativity.
|
31649580 |
2019 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use.
|
27353026 |
2017 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.
|
25858800 |
2015 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the schizophrenia risk allele (T) of rs6994992 conferred lower cortical NRG1-IVNV levels.
|
24935406 |
2014 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.
|
24865593 |
2014 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three variants and one microsatellite showed allelic association with SZ (rs35753505, rs4733263, rs6994992, and microsatellite 420M9-1395, p≤0.05 uncorrected for multiple comparisons).
|
23360725 |
2013 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this cross-sectional genetic association study was to determine the relationship of six core single-nucleotide polymorphisms within the NRG1 gene identified as promising schizophrenia risk genes (rs6994992, SNP8NRG221132, SNP8NRG241930, rs3924999, rs2439272 and rs10503929) to prepulse inhibition (PPI) of the acoustic startle reflex, a well validated schizophrenia endophenotype.
|
21035784 |
2011 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, taking into account the rs6994992 SNP in the NRG1 gene, which was also associated with LV volume in a previous study, the DISC1 SNP only predicted LV enlargement among those patients carrying the T allele in the NRG1 SNP.
|
19913623 |
2010 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.
|
18543275 |
2009 |
|
rs6994992
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition.
|
18286587 |
2008 |