|
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both CACNA1C (rs1006737) and KCNH2 (rs3800779) were genotyped in 101 controls and 50 schizophrenia patients.
|
30607529 |
2019 |
|
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia.
|
31033230 |
2019 |
|
rs12807809
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings are the first to suggest an association between rs12807809 and abnormal Papez circuit function in patients with SZ.
|
30953482 |
2019 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia.
|
30852803 |
2019 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs1344706 risk allele carriers of schizophrenia had increased gray matter in the brain regions including frontal lobe, temporal lobe, and other brain regions, but the carriers of healthy individuals had decreased gray matter and white matter integrity in the frontal lobe, central network, and other brain regions.
|
30962687 |
2019 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Previous studies indicated that single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A was strongly associated with schizophrenia and might influence social interaction.
|
31122238 |
2019 |
|
rs1625579
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, whether the influence of rs1625579 on schizophrenia in the Asian population is consistent with these results remains unclear.
|
31586698 |
2019 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Nevertheless, we could not replicate the association of rs1344706 with schizophrenia</span>.
|
29112096 |
2018 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The biological function of ZNF804A rs1344706, the first genome-wide supported risk variant of schizophrenia, remains largely unknown.
|
28078547 |
2018 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The homozygous ZNF804A rs1344706 genotype (AA) conferred a high risk of sc</span>hizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC (F(2,165) = 13.43, P < 0.001).
|
29611035 |
2018 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Neither univariate nor multivariate analyses showed any associations between indices of grey matter and rs1344706 variation in schizophrenia or healthy participants.
|
29247760 |
2018 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three SNPs (rs1625579, rs1344706 and rs4765905) showed a consistent direction of effect with previous studies and the polygenic risk score constructed using the weighted sum of these three SNPs showed a significant association with Schizophrenia in this population (OR=3.78, p=0.005).
|
29599094 |
2018 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results elucidated the contribution of rs1344706 to functional connectivity within the brain network, and may have important implications for our understanding of this risk gene's role in functional dysconnectivity in schizophrenia.
|
29527501 |
2018 |
|
rs1625579
|
|
|
0.900 |
GeneticVariation |
BEFREE |
<i>MIR137</i> rs1625579 polymorphism might be an important sex-dependent factor influencing severity of schizophrenia psychopathological manifestations.
|
30026708 |
2018 |
|
rs1625579
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Taken together, rs1625579 seems to play an important role in both functional and structural connectivity between the PCC and the ACC/MPFC, which may serve as the brain mechanisms for the link between rs1625579 and schizophrenia.
|
30035013 |
2018 |
|
rs1625579
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three SNPs (rs1625579, rs1344706 and rs4765905) showed a consistent direction of effect with previous studies and the polygenic risk score constructed using the weighted sum of these three SNPs showed a significant association with Schizophrenia in this population (OR=3.78, p=0.005).
|
29599094 |
2018 |
|
rs1625579
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Schizophrenia patients with the MIR137 rs1625579 risk genotype (homozygous for the schizophrenia risk variant) also have aberrant brain structure.
|
28958479 |
2018 |
|
rs1625579
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Polymorphisms of the rs1625579 locus in the <i>miR-13</i> gene are associated with schizophrenia susceptibility, and high glucose-induced upregulation of miR-137 in vascular endothelial cells promotes monocyte chemotaxis and inflammatory cytokine secretion in gestational diabetes mellitus.
|
30122962 |
2018 |
|
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
|
rs12807809
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed an association of rs12807809 with SCZ in this study population.
|
28389239 |
2017 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005).
|
28120939 |
2017 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Put in perspective, ZNF804A rs1344706, not only had a significant main effect, but its SZ-specific effects were two orders of magnitude more widespread than that of CACNA1C rs1006737.
|
27790829 |
2017 |
|
rs1344706
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our result suggests that genetic variant rs1344706 might be associated with the development of schizophrenia in Asians.
|
28883732 |
2017 |