rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate the effects of ACE insertion/deletion (I/D) and endothelial nitric oxide synthase (eNOS) Glu298Asp (G894-->T) and T-786-->C polymorphisms in patients with systemic sclerosis.
|
12015245 |
2002 |
rs1177506410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate the effects of ACE insertion/deletion (I/D) and endothelial nitric oxide synthase (eNOS) Glu298Asp (G894-->T) and T-786-->C polymorphisms in patients with systemic sclerosis.
|
12015245 |
2002 |
rs1275805226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate the effects of ACE insertion/deletion (I/D) and endothelial nitric oxide synthase (eNOS) Glu298Asp (G894-->T) and T-786-->C polymorphisms in patients with systemic sclerosis.
|
12015245 |
2002 |
rs755460305
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate the effects of ACE insertion/deletion (I/D) and endothelial nitric oxide synthase (eNOS) Glu298Asp (G894-->T) and T-786-->C polymorphisms in patients with systemic sclerosis.
|
12015245 |
2002 |
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results are different from a previous study in which the frequency of the T/T allele was high in SSc at T869C (Leu10Pro).
|
12207584 |
2002 |
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results indicate that eNOS (G894T) and p22(phox) (C242T) polymorphisms do not influence susceptibility to and the course of systemic sclerosis.
|
15530459 |
2004 |
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In Iranian patients, susceptibility to SSc is not influenced by a bi-allelic ctla-4 gene (A49G) polymorphism.
|
16189655 |
2006 |
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Hemorheologic profile in systemic sclerosis: role of NOS3 -786T > C and 894G >T polymorphisms in modulating both the hemorheologic parameters and the susceptibility to the disease.
|
16802365 |
2006 |
rs2243204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed four IL13 gene polymorphisms, rs1800925 (IL13-1055), rs20541 (Arg130Gln), rs847, and rs2243204 in 107 unrelated SSc patients (40 patients having diffuse cutaneous form and 67 patients having limited cutaneous form) and in 170 controls.All subjects were Caucasians.
|
16832637 |
2006 |
rs2476601
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis.
|
16870103 |
2006 |
rs638376
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected an association between IL13RA2 rs638376 and patients with SSc [p = 0.004, odds ratio (OR) = 1.85, confidence interval (CI) 1.22-2.74, p corr = 0.02], as well as with dcSSc in that subgroup of patients (p = 0.01, OR 2.22, 95% CI 1.27-3.89, p corr = 0.05).
|
16981293 |
2006 |
rs2476601
|
|
|
0.760 |
GeneticVariation |
BEFREE |
The association of subsets of SSc with the PTPN22 R620W polymorphism further strengthens the classification of SSc within the spectrum of autoimmune diseases and strongly suggests the involvement of common susceptibility genes and similarly disordered immunoregulatory pathways.
|
17133608 |
2006 |
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We investigated haemorheological variables in patients with idiopathic sudden sensorineural hearing loss (ISSHL), retinal vein occlusion (RVO) and systemic sclerosis (SSc), as possible models of microvascular damage, and their relationship with eNOS gene T-786C, G894T and 4a/4b polymorphisms.
|
17634663 |
2007 |
rs17235409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed four natural resistance associated macrophage protein 1 (NRAMP1) gene polymorphisms including 5' promoter (GT)n microsatellite, INT4 (469 + 14G/C), 3'UTR (1729 + 55del4), and D543N (codon 543, Asp to Asn) in 52 systemic sclerosis patients with interstitial lung involvement and 136 healthy controls.
|
17876529 |
2008 |
rs1130866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in the surfactant proteins in systemic sclerosis in Japanese: T/T genotype at 1580 C/T (Thr131Ile) in the SP-B gene reduces the risk of interstitial lung disease.
|
18263595 |
2008 |
rs1322403577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in the surfactant proteins in systemic sclerosis in Japanese: T/T genotype at 1580 C/T (Thr131Ile) in the SP-B gene reduces the risk of interstitial lung disease.
|
18263595 |
2008 |
rs1372834938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While no association was found between SSc and -819C/T, -592C/A polymorphism, -1082 G/A allele frequency in SSc patients was higher than that in control and significant association was found between SSc and -1082 G/A (Pc: <0.000, OR: 2.85 95% CI: 1.74-4.63).
|
18493769 |
2008 |
rs2476601
|
|
|
0.760 |
GeneticVariation |
BEFREE |
We then conducted a meta-analysis of the most recent studies of SSc in order to verify the association or lack of association between the PTPN22 1858C>T variant and SSc.</span>
|
18576360 |
2008 |
rs2834167
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype A/A at rs2834167 (47K/K) was significantly increased in diffuse cutaneous SSc (dcSSc) (41.3% in dcSSc, 20.9% in controls, P=0.0018, odds ratio=2.67).
|
18588853 |
2008 |
rs999788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A SNP in the 5' flanking region of IL10RB, rs999788, also showed association with dcSSc; however, this association was shown to be secondarily caused by linkage disequilibrium with rs2834167.
|
18588853 |
2008 |
rs17612648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians.
|
18634151 |
2008 |
rs6314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The His452Tyr substitution may influence susceptibility to systemic sclerosis by altering platelet aggregation in response to serotonin.
|
18761744 |
2008 |
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of MTHFR C677T mutation influences the incidence of macrovascular abnormalities in SSc patients.
|
19093229 |
2009 |
rs2004640
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The IRF5 rs2004640 GT substitution is associated with susceptibility to SSc.
|
19116937 |
2009 |
rs4362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two supplementary exonic SNP of ACE gene (rs4309, rs4362) were genotyped in 659 patients with SSc and 511 matched healthy controls.
|
19132786 |
2009 |