Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2670660
rs2670660
NLRP1
0.010 GeneticVariation BEFREE /st> To study a possible association of the NLRP1 rs6502867, rs2670660 and rs8182352, rs12150220 and rs4790797 with SSc in the European Caucasian population. 21149496

2011
dbSNP: rs12150220
rs12150220
NLRP1
0.010 GeneticVariation BEFREE /st> To study a possible association of the NLRP1 rs6502867, rs2670660 and rs8182352, rs12150220 and rs4790797 with SSc in the European Caucasian population. 21149496

2011
dbSNP: rs4790797
rs4790797 		0.010 GeneticVariation BEFREE /st> To study a possible association of the NLRP1 rs6502867, rs2670660 and rs8182352, rs12150220 and rs4790797 with SSc in the European Caucasian population. 21149496

2011
dbSNP: rs4898
rs4898
SYN1 ; TIMP1 ; MIR4769
0.010 GeneticVariation BEFREE A candidate gene for TIMP-1 gene located on the X-chromosome (rs4898) was selected for a control case study to investigate a possible association of this SNP with the susceptibility to systemic sclerosis and its digit ulcer manifestation. 22820628

2012
dbSNP: rs6672420
rs6672420
RUNX3 ; LOC105376878
0.010 GeneticVariation BEFREE A higher methylation status of the <i>RUNX3</i> gene, which is associated with polymorphism rs6672420, correlates with lower <i>RUNX3</i> expression and SSc susceptibility. 31126957

2019
dbSNP: rs35705950
rs35705950 		0.010 GeneticVariation BEFREE A polymorphism on the MUC5B promoter (rs35705950) has been associated with idiopathic pulmonary fibrosis (IPF) but not with systemic sclerosis (SSc) with interstitial lung disease (ILD). 23940607

2013
dbSNP: rs1234314
rs1234314
TNFSF4
0.020 GeneticVariation BEFREE A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). 21187296

2011
dbSNP: rs12039904
rs12039904
TNFSF4 ; LOC100506023
0.020 GeneticVariation BEFREE A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). 21187296

2011
dbSNP: rs10516487
rs10516487
BANK1
0.020 GeneticVariation BEFREE A significant association of the rs10516487 G and rs17266594 T alleles with SSc susceptibility was observed (pooled OR=1.12, 95% CI 1.03 to 1.22; p=0.01 and pooled OR=1.14, 95% CI 1.05 to 1.25; p=0.003, respectively), whereas the rs3733197 genetic variant showed no statistically significant deviation. 19815934

2010
dbSNP: rs3733197
rs3733197
BANK1
0.020 GeneticVariation BEFREE A significant association of the rs10516487 G and rs17266594 T alleles with SSc susceptibility was observed (pooled OR=1.12, 95% CI 1.03 to 1.22; p=0.01 and pooled OR=1.14, 95% CI 1.05 to 1.25; p=0.003, respectively), whereas the rs3733197 genetic variant showed no statistically significant deviation. 19815934

2010
dbSNP: rs17266594
rs17266594
BANK1
0.010 GeneticVariation BEFREE A significant association of the rs10516487 G and rs17266594 T alleles with SSc susceptibility was observed (pooled OR=1.12, 95% CI 1.03 to 1.22; p=0.01 and pooled OR=1.14, 95% CI 1.05 to 1.25; p=0.003, respectively), whereas the rs3733197 genetic variant showed no statistically significant deviation. 19815934

2010
dbSNP: rs999788
rs999788
IFNAR2 ; IL10RB ; IL10RB-DT
0.010 GeneticVariation BEFREE A SNP in the 5' flanking region of IL10RB, rs999788, also showed association with dcSSc; however, this association was shown to be secondarily caused by linkage disequilibrium with rs2834167. 18588853

2008
dbSNP: rs2736340
rs2736340 		0.820 GeneticVariation GWASCAT A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs2736340
rs2736340 		0.820 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs13239597
rs13239597
TNPO3 ; TPI1P2
0.810 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs13239597
rs13239597
TNPO3 ; TPI1P2
0.810 GeneticVariation GWASCAT A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs10498070
rs10498070 		0.800 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs10498070
rs10498070 		0.800 GeneticVariation GWASCAT A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs10499197
rs10499197 		0.800 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs10499197
rs10499197 		0.800 GeneticVariation GWASCAT A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs1133906
rs1133906
SAMD9L
0.800 GeneticVariation GWASCAT A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs1133906
rs1133906
SAMD9L
0.800 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs11860650
rs11860650
ITGAM
0.800 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs11860650
rs11860650
ITGAM
0.800 GeneticVariation GWASCAT A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs12711490
rs12711490 		0.800 GeneticVariation GWASCAT A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013