rs7574865
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
rs7574865
|
|
T |
0.870 |
GeneticVariation |
GWASCAT |
Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
|
28314753 |
2017 |
rs7574865
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The results demonstrated that STAT4 rs7574865 and IRF5 rs2004640G/T substitution are associated with a susceptibility to SSc, and they may serve as the SSc genetic susceptibility factor.
|
26712637 |
2016 |
rs7574865
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc).
|
23755762 |
2013 |
rs7574865
|
|
|
0.870 |
GeneticVariation |
BEFREE |
We found a significant association between SSc and STAT rs7574865 (TT vs. GG: OR 0.44, 95% CI 0.36-0.54; TT vs. TG + GG: OR 0.48, 95% CI 0.39-0.59; TT + TG vs. GG: OR 0.74, 95% CI 0.66-0.83; T vs. G: OR 0.72, 95% CI 0.66-0.79), but there were no other statistically significant associations with other gene polymorphisms.
|
22173230 |
2012 |
rs7574865
|
|
T |
0.870 |
GeneticVariation |
GWASCAT |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
rs7574865
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA.
|
21149496 |
2011 |
rs7574865
|
|
T |
0.870 |
GeneticVariation |
GWASDB |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
rs7574865
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The association of the rs7574865 T allele with lcSSc was confirmed in all the replication cohorts with different effect sizes (OR ranging between 1.15 and 1.86), as well as the lack of association of STAT4 with dcSSc.
|
19286670 |
2009 |
rs7574865
|
|
|
0.870 |
GeneticVariation |
BEFREE |
An additive effect of the STAT4 rs7574865 T allele and the IRF5 rs2004640 T allele was observed, resulting in a multiple increased 1.28-fold risk of SSc.
|
19644887 |
2009 |
rs3821236
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.
|
31672989 |
2019 |
rs7601754
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
rs7601754
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
rs3821236
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|
21779181 |
2011 |
rs3821236
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|
21779181 |
2011 |
rs3821236
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
rs3821236
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
rs10174238
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
rs13389408
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
rs10174238
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.
|
29293537 |
2018 |
rs11893432
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.
|
29293537 |
2018 |
rs11893432
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.
|
24387989 |
2014 |
rs10168266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc).
|
23755762 |
2013 |
rs11889341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In an analysis of 1,039 SSc patients and 3,322 controls, the A allele of the STAT4 variant rs11889341 was associated with increased SSc susceptibility in a dominant pattern (Pcorr=2.4x10(-5), odds ratio 1.29, 95% confidence interval 1.2-1.5).
|
19950257 |
2009 |