Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1554162524
rs1554162524
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1556408009
rs1556408009
T 0.700 CausalMutation CLINVAR

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models. 27958344

2016

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. 25454804

2015

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). 25427560

2015

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. 21968286

2012

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE The odds ratio for the association of Asp299Gly polymorphism with sepsis</span> risk was 1.22 (95% CI: 0.90-1.65, P=0.21), and the association of Thr399Ile polymorphism was 1.16 (95%CI: 0.70-1.91, P=0.57). 22537674

2012

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE Six haplotype-tagging SNPs in the TLR4 gene were subsequently examined to analyze their influence on TLR4 A896G SNPs relationship to sepsis severity. 19131814

2009

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. 18034244

2008

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery the presence of TLR4(D299G) mutation was analysed in 307 Caucasian patients (154 without and 153 with sepsis). 12807489

2003

dbSNP: rs4986790
rs4986790
0.090 GeneticVariation BEFREE Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. 12404174

2002

dbSNP: rs4986791
rs4986791
0.070 GeneticVariation BEFREE We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models. 27958344

2016

dbSNP: rs4986791
rs4986791
0.070 GeneticVariation BEFREE Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. 25454804

2015

dbSNP: rs4986791
rs4986791
0.070 GeneticVariation BEFREE Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). 25427560

2015

dbSNP: rs4986791
rs4986791
0.070 GeneticVariation BEFREE In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. 21968286

2012

dbSNP: rs4986791
rs4986791
0.070 GeneticVariation BEFREE The odds ratio for the association of Asp299Gly polymorphism with sepsis risk was 1.22 (95% CI: 0.90-1.65, P=0.21), and the association of Thr399Ile</span> polymorphism was 1.16 (95%CI: 0.70-1.91, P=0.57). 22537674

2012

dbSNP: rs4986791
rs4986791
0.070 GeneticVariation BEFREE Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. 18034244

2008

dbSNP: rs4986791
rs4986791
0.070 GeneticVariation BEFREE Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. 12404174

2002

dbSNP: rs1800629
rs1800629
TNF
0.050 GeneticVariation BEFREE Our results suggest that the G/A genotype of <i>TNF-α</i> rs1800629 and rs361525 increases sepsis risk in an Asian population. 29340067

2017

dbSNP: rs1800629
rs1800629
TNF
0.050 GeneticVariation BEFREE We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10. 27592234

2016

dbSNP: rs1800629
rs1800629
TNF
0.050 GeneticVariation BEFREE In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis. 26025100

2015

dbSNP: rs1800629
rs1800629
TNF
0.050 GeneticVariation BEFREE The minor allele frequency of rs1800629 was significantly higher in severe sepsis patients than that in both healthy controls (P(adj) = 0.00046, odds ratio (OR)(adj) = 1.92) and sepsis patients (P(adj) = 0.002, OR(adj) = 1.56). 23029405

2012

dbSNP: rs1800629
rs1800629
TNF
0.050 GeneticVariation BEFREE Carriage of the TNF rs1800629 A allele was associated with higher TNF-alpha serum concentrations on the first day after trauma and during follow-up (two-sided p = 5.0 x 10(-5)), with development of sepsis syndrome (odds ratio 7.14, two-sided p = 1.2 x 10(-6); external validation sample [n = 76]: odds ratio 3.3, one-sided p = .03), and with fatal outcome (odds ratio 7.65, two-sided p = 1.9 x 10(-6)). 18434886

2008

dbSNP: rs1800625
rs1800625
0.030 GeneticVariation BEFREE Significant differences were observed in the rs1800624 and rs1800625 genotype/allele distributions between the sepsis and controls, but no significant difference was observed in the rs2070600 genotype/allele. 27172264

2017

dbSNP: rs1800625
rs1800625
0.030 GeneticVariation BEFREE The rs1800625 polymorphism is a functional single nucleotide polymorphism and confers host susceptibility to sepsis and MODS in patients with major trauma. 25572180

2015