Subjects carrying allele C of rs1042522 were associated with an increased risk of occupational skin neoplasms [<i>P</i>=0.027, odds ratio (OR)=1.97, 95% confidence intervals (CI) 1.08-3.63].
Here, we show, using conditional mouse technology, that epithelium-specific heterozygous expression of mutant p53 (i.e., the p53.R270H mutation that is equivalent to the human hotspot R273H) results in an increased incidence of spontaneous and UVB-induced skin tumors.