Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.890 | GeneticVariation | BEFREE | No significant difference was found between the AS susceptibility and polymorphisms of rs27044 and rs27434. | 30461632 | 2018 |
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0.890 | GeneticVariation | BEFREE | Our results indicated a difference in the mechanism of susceptibility loci in subsets of Zhejiang Han Chinese population and provided further evidence that rs27434 is the key polymorphism associated with AS in ERAP1 gene. | 26350268 | 2016 |
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0.890 | GeneticVariation | BEFREE | ERAP1 gene rs27434 and rs7711564 polymorphisms may increase the risk of AS. | 26617903 | 2015 |
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0.890 | GeneticVariation | BEFREE | Our study also confirmed a weak association between ERAP1 (rs27434) and AS. | 24666027 | 2014 |
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0.890 | GeneticVariation | BEFREE | Except in rs27434 (P = 0.23), the significant correlation between ERAP1 polymorphisms and AS susceptibility has been detected in rs27044 (OR 1.57, P < 0.001), rs17482078 (OR 1.271, P < 0.001), rs10050860 (OR 0.772, P = 0.006), rs30187 (OR 1.348, P < 0.001), rs2287987 (OR 0.746, P < 0.001) and rs27037 (OR 1.257, P = 0.001). | 21229357 | 2012 |
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0.890 | GeneticVariation | BEFREE | Two specific haplotypes including: rs30187/ rs469876/ rs13167972/ rs27434 TAAA and CAGG were associated with increased and decreased risk of AS in Iranian population, respectively. | 23264405 | 2012 |
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0.890 | GeneticVariation | BEFREE | This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS. | 21041274 | 2011 |
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0.890 | GeneticVariation | BEFREE | Two SNP (rs27434, p = 0.00039, and rs27529, p = 0.0083) in ERAP1 other than that reported previously were found to be significantly associated with AS. | 21078719 | 2011 |
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A | 0.890 | GeneticVariation | GWASCAT | Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. | 20062062 | 2010 |
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A | 0.890 | GeneticVariation | GWASDB | Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. | 20062062 | 2010 |
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0.890 | GeneticVariation | BEFREE | We report several new associations between AS and polymorphisms distributed across ERAP1 from the extended case-control study, the most significant of which was with rs27434 (P = 4.7 x 10(-7)). | 19692350 | 2009 |