The novel 9175th- (exon 7) position polymorphism of <i>OPN</i> and rs17524488 were related to susceptibility to AS in a Chinese population, the rs17524488 G/G genotype may be involved in the pathogenesis of AS, and the precise molecular mechanism underlying the influence of <i>OPN</i> polymorphisms on the development of AS remains to be determined in the further prospective studies.