DisGeNET - a database of gene-disease associations

Ankylosing spondylitis, C0038013

Variant: rs26653 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs26653

ERAP1

0.030

GeneticVariation

BEFREE

The ERAP1 (rs26653) polymorphism was found to increase the disease risk in patients with AS and IBD compared with the control group (p=0.02 and p=0.01, respectively).

27458846

2016

dbSNP:

rs26653

ERAP1

0.030

GeneticVariation

BEFREE

Overall, six SNPs were associated with AS; two SNPs (rs27044 and rs26653) were not when all studies were pooled into the meta-analysis (rs27044 G vs. C, OR = 1.058, 95% CI = 0.827-1.354; rs26653 C vs. G, OR = 1.154, 95% CI = 0.937-1.422).

25401226

2015

dbSNP:

rs26653

ERAP1

0.030

GeneticVariation

BEFREE

The contributions of HLA-B27 and the rs26653 SNP to AS pathogenesis appear to be independent.

23864143

2013