|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population.
|
30794838 |
2019 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was statistically association between ERAP1 rs27044 polymorphism and risk of AS, and the carriers with rs27044 CG genotype have an increased the risk for AS (CG versus GG, OR=1.70, 95% CI=1.10-2.62, P=0.015).
|
29278768 |
2018 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results It was seen that G allele and GG genotype of rs27044 SNP significantly increased the risk of AS that was even stronger in HLA-B27 positive patients.
|
30412714 |
2018 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant difference was found between the AS susceptibility and polymorphisms of rs27044 and rs27434.
|
30461632 |
2018 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It was observed that the G allele of rs27044 polymorphism was significantly prevalent in AS patients.
|
30518188 |
2018 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The risk of AS is increased in patients possessing endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphisms rs30187 and rs27044 encoding amino acid changes K528R and Q730E, respectively.
|
26321090 |
2016 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AS-protective ERAP1 variants, K528R and Q730E, were associated with reduced surface FHC expression by monocytes from patients with AS and HLA-B27-expressing APCs.
|
26130142 |
2016 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, six SNPs were associated with AS; two SNPs (rs27044 and rs26653) were not when all studies were pooled into the meta-analysis (rs27044 G vs. C, OR = 1.058, 95% CI = 0.827-1.354; rs26653 C vs. G, OR = 1.154, 95% CI = 0.937-1.422).
|
25401226 |
2015 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For the general group of AS, the carriers of minor alleles showed an increased risk for the disease (OR 1.92, 95% CI 1.17-3.13 for rs30187, OR 1.74, 95% CI 1.08-2.80 for rs27044).
|
23800305 |
2013 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, two cSNPs (rs27044 and rs30187) strongly associated with HLA-B27 positivity in AS patients.
|
22632381 |
2012 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Strong association with AS was observed for marker rs27044, but no significant differences were observed between AS patients and controls in the frequencies of the carriership of the alleles rs55704465 and rs1800470.
|
21833528 |
2012 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Except in rs27434 (P = 0.23), the significant correlation between ERAP1 polymorphisms and AS susceptibility has been detected in rs27044 (OR 1.57, P < 0.001), rs17482078 (OR 1.271, P < 0.001), rs10050860 (OR 0.772, P = 0.006), rs30187 (OR 1.348, P < 0.001), rs2287987 (OR 0.746, P < 0.001) and rs27037 (OR 1.257, P = 0.001).
|
21229357 |
2012 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans.
|
21877190 |
2011 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carriage of the G allele of rs27044 was significantly associated with the HLA-B*2705 subtype (p = 0.009) in AS patients.
|
20032103 |
2010 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNPs rs27044 (p=9.37 x 10(-7)) and rs30187 (p=7.16 x 10(-6)) of ARTS1 were significantly associated with AS in Koreans.
|
19414429 |
2010 |
|
rs27044
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A specific ERAP1 haplotype, rs27044/10050860/30187-CCT, was strongly associated with increased risk of AS in all 3 case-control cohorts (pooled odds ratio [OR] 1.81, 95% confidence interval [95% CI] 1.46-2.24; P=7x10(-8)), while a second specific ERAP1 haplotype, rs30187/26618/26653-CTG, reduced the disease risk (pooled OR 0.77, 95% CI 0.67-0.88; P=9x10(-5)).
|
19404951 |
2009 |