Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs34743033
rs34743033
0.020 GeneticVariation BEFREE The 2R2R genotype (rs34743033) was not significantly associated with developing MTX-induced oral mucositis compared with the 2R3R/3R3R genotypes, which was confirmed in a meta-analysis [odds ratio (OR): 1.17 (0.62-2.19)]. 30222710

2018

dbSNP: rs34743033
rs34743033
0.020 GeneticVariation BEFREE MTX AUC0-48h was a significant predictor of overall toxic adverse events during MTX courses (R(2) = 0.043; P < .001), whereas the thymidylate synthase rs34743033 tandem repeat polymorphism was predictive of stomatitis (R(2) = 0.018; P = .009), a frequent side effect of high-dose MTX. 23652803

2013

dbSNP: rs151264360
rs151264360
0.010 GeneticVariation BEFREE The 6-bp deletion [rs151264360, OR: 0.79 (0.20-3.19)] was not associated with the development of MTX-induced oral mucositis. 30222710

2018

dbSNP: rs1629816
rs1629816
0.010 GeneticVariation BEFREE The purpose of this study was to investigate the relationship between single nucleotide polymorphisms (SNP; rs1629816) in the regulatory region (c.-2531C>T) of the ghrelin (GHRL) gene and the occurrence and severity of oral mucositis caused by radiotherapy (RT) in patients with head and neck cancer. 29566446

2018

dbSNP: rs4149570
rs4149570
0.010 GeneticVariation BEFREE Our results indicate an association between SNP of TNFRSF1A (rs4149570) gene and risk of more severe OM related to radiation therapy for HNC patients. 28401452

2018

dbSNP: rs4855883
rs4855883
0.010 GeneticVariation BEFREE Polymorphism of regulatory region of APEH gene (c.-521G>C, rs4855883) as a relevant predictive factor for radiotherapy induced oral mucositis and overall survival in head neck cancer patients. 30038710

2018

dbSNP: rs10505168
rs10505168
0.010 GeneticVariation BEFREE Oral mucositis was defined as grade more than or equal to 3 according to the National Cancer Institute criteria. rs2114358 in miR-1206 was associated with oral mucositis [odds ratio (OR): 3.6; 95% confidence interval (CI): 1.1-11.5], whereas we did not confirm the association of CNOT4 rs3812265 (OR: 0.69; 95% CI: 0.27-1.80) and miR-2053 rs10505168 (OR: 2.50; 95% CI: 0.76-8.24). 28628559

2017

dbSNP: rs11081899
rs11081899
0.010 GeneticVariation BEFREE These findings suggested that rs11081899-A may be a genetic susceptibility factor for radiation-induced OM in patients with NPC, although its value in clinical application needs to be further verified in a large cohort. 28968968

2017

dbSNP: rs12676482
rs12676482
0.010 GeneticVariation BEFREE In some subgroups, cyclin D1 gene CCND1 rs9344 and inhibitor of κB kinase gene IKBKB rs12676482 were related with the grade 3-4 acute radiation-induced myelosuppression, and CCND1 rs9344 was also associated with grade 3-4 acute radiation-induced oral mucositis. 28445979

2017

dbSNP: rs2114358
rs2114358
0.010 GeneticVariation BEFREE Oral mucositis was defined as grade more than or equal to 3 according to the National Cancer Institute criteria. rs2114358 in miR-1206 was associated with oral mucositis [odds ratio (OR): 3.6; 95% confidence interval (CI): 1.1-11.5], whereas we did not confirm the association of CNOT4 rs3812265 (OR: 0.69; 95% CI: 0.27-1.80) and miR-2053 rs10505168 (OR: 2.50; 95% CI: 0.76-8.24). 28628559

2017

dbSNP: rs3812265
rs3812265
0.010 GeneticVariation BEFREE Oral mucositis was defined as grade more than or equal to 3 according to the National Cancer Institute criteria. rs2114358 in miR-1206 was associated with oral mucositis [odds ratio (OR): 3.6; 95% confidence interval (CI): 1.1-11.5], whereas we did not confirm the association of CNOT4 rs3812265 (OR: 0.69; 95% CI: 0.27-1.80) and miR-2053 rs10505168 (OR: 2.50; 95% CI: 0.76-8.24). 28628559

2017

dbSNP: rs744166
rs744166
0.010 GeneticVariation BEFREE Both multiple logistic regression analysis and Cox proportional-hazards regression analysis show STAT3 rs744166 TT+TC genotypes and serum creatinine in each patient were significant independent factors for stomatitis development. 28381801

2017

dbSNP: rs9344
rs9344
0.010 GeneticVariation BEFREE In some subgroups, cyclin D1 gene CCND1 rs9344 and inhibitor of κB kinase gene IKBKB rs12676482 were related with the grade 3-4 acute radiation-induced myelosuppression, and CCND1 rs9344 was also associated with grade 3-4 acute radiation-induced oral mucositis. 28445979

2017

dbSNP: rs1801133
rs1801133
0.010 GeneticVariation BEFREE A gene-gene interaction between MTRR (rs1801394) and MTHFR (rs1801133) was detected by GMDR and proved to have an independent effect on the risk of stomatitis, as shown by LR analysis. 27452984

2016

dbSNP: rs1801394
rs1801394
0.010 GeneticVariation BEFREE A gene-gene interaction between MTRR (rs1801394) and MTHFR (rs1801133) was detected by GMDR and proved to have an independent effect on the risk of stomatitis, as shown by LR analysis. 27452984

2016

dbSNP: rs375557
rs375557
0.010 GeneticVariation BEFREE Moreover, GSK3β rs375557 and adenomatous polyposis coli gene (APC) rs454886 polymorphisms were correlated with acute grade 3-4 radiation-induced dermatitis and oral mucositis, respectively. 27769064

2016

dbSNP: rs454886
rs454886
APC
0.010 GeneticVariation BEFREE Moreover, GSK3β rs375557 and adenomatous polyposis coli gene (APC) rs454886 polymorphisms were correlated with acute grade 3-4 radiation-induced dermatitis and oral mucositis, respectively. 27769064

2016

dbSNP: rs1110277
rs1110277
0.010 GeneticVariation BEFREE The rs4987219 and rs1110277 correlated with severe acute leukopenia (p=0.025) and stomatitis (p=0.019), respectively. 24578608

2014

dbSNP: rs4987219
rs4987219
0.010 GeneticVariation BEFREE The rs4987219 and rs1110277 correlated with severe acute leukopenia (p=0.025) and stomatitis (p=0.019), respectively. 24578608

2014

dbSNP: rs775144154
rs775144154
0.010 GeneticVariation BEFREE In addition, there was a trend toward reduced hematological toxicity among patients with variants of SLC19A1 G80A in treatment arm 1 (P for trend, .06) and reduced esophagitis/stomatitis noted among patients with variants of TSER in treatment arm 3 (P for trend, .06). 25041994

2014

dbSNP: rs25487
rs25487
0.010 GeneticVariation BEFREE Our investigation shows, for the first time, that patients with the XRCC1 399Arg/Gln genotype were more likely to experience severe acute dermatitis and oral mucositis. 23375119

2013

dbSNP: rs1045642
rs1045642
0.010 GeneticVariation BEFREE Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with acute lymphoblastic leukemia? 23244145

2012

dbSNP: rs1217691063
rs1217691063
0.010 GeneticVariation BEFREE Results suggested that MTHFR C677T polymorphism was associated with significantly increased risk of MTX-induced toxicity, specifically liver toxicity (TT/CT vs. CC: odds ratio (OR) = 1.70, 95 % confidence interval (CI) = 1.05-2.75), myelosuppression (TT vs. CT/CC: OR = 2.82, 95 %CI = 1.25-6.34), oral mucositis (TT/CT vs. CC: OR = 3.68, 95 %CI = 1.73-7.85), gastrointestinal toxicity (TT/CT vs. CC: OR = 2.36, 95 %CI = 1.36-4.11), and skin toxicity (T vs. C: OR = 2.26, 95 %CI = 1.07-4.74). 22528943

2012