Gene: MTHFR ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE MTHFR C677T was prevalent among patients with recurrent stroke. 21824561

2011
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE C677T MTHFR mutation and factor V Leiden mutation in patients with TIA/minor stroke: a case-control study. 9950259

1999
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE A recent study of children demonstrated that the homozygous form of C677T polymorphism occurred two-times as often in those with stroke versus healthy controls. 16282888

2005
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE A significant combined effect on stroke due to the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR), the T2354A polymorphism of 5-lipoxygenase activating protein (ALOX5AP), and Lp(a) level, was detected using the MDR method. 17521309

2007
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE According to our results, the C677T mutation does not constitute a major risk factor for transient ischemic attack or minor stroke, even under consideration of other possibly confounding factors that are known to affect plasma homocysteine levels. 10360632

1999
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE After excluding articles that deviated from the Hardy-Weinberg equilibrium in controls and the key contributors to between-study heterogeneity, significant associations between the MTHFR C677T genetic polymorphism and the risk of hemorrhagic stroke were observed in dominant (Odds ratio [OR] 1.611, 95% confidence interval [CI] 1.336-1.942), codominant (OR 1.500, 95% CI 1.330-1.692), and recessive (OR 1.695, 95% CI 1.409-2.038) models. 23428159

2013
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Fasting total plasma homocysteine (tHcy) concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype were determined in 25 patients with sCAD, 31 patients <45 years of age with non-CAD ischemic stroke, and 36 control subjects. 11872884

2002
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Further large-scale genetic studies of the association between MTHFR 677C→T and stroke in low folate settings are needed to distinguish effect modification by folate from small-study bias. 21803414

2011
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Genotyping of methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation and brain MRI examination were performed in 1721 subjects free of any history of stroke. 12690212

2003
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Homocysteine and Stroke Risk: Modifying Effect of Methylenetetrahydrofolate Reductase C677T Polymorphism and Folic Acid Intervention. 28360116

2017
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Homozygous MTHFR C677T gene mutation and recurrent stroke in an infant. 16814086

2006
dbSNP: rs397507444
rs397507444
MTHFR
0.080 GeneticVariation BEFREE In conclusion, the overall analysis suggests that MTHFR gene A1298C polymorphism plays an important role in the development of adult stroke. 25472665

2014
dbSNP: rs397507444
rs397507444
MTHFR
0.080 GeneticVariation BEFREE In conclusion, this meta-analysis supported that the MTHFR A1298C polymorphism could be capable of increasing stroke susceptibility in Asian, but not in Caucasian, populations. 24391036

2013
dbSNP: rs1801133
rs1801133
MTHFR
0.040 GeneticVariation BEFREE In the stratified analyses, significantly increased stroke risks were indicated among Asians in all genetic models (homozygote model: OR 1.726, 95% CI 1.314-2.267; dominant model: OR 1.535, 95% CI 1.282-1.838; recessive model: OR 1.452, 95% CI 1.160-1.818; allele comparison model: OR 1.403, 95% CI 1.211-1.626).The present meta-analysis suggests that rs1801133 polymorphism contributes to the risk of stroke, of note, in Asian populations. 25107455

2015
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE In view of the prevailing controversy about the role of Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in stroke and paucity of studies from India, this study has been undertaken to evaluate MTHFR C677T gene polymorphism in consecutive ischemic stroke patients and correlate these with folic acid, homocysteine (Hcy) and conventional risk factors. 16936384

2006
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Individuals homozygous for the T allele of the MTHFR C677T polymorphism have higher plasma homocysteine concentrations (the phenotype) than those with the CC genotype, which, if pathogenetic, should put them at increased risk of stroke. 15652605

2005
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE It is still controversial whether elevated plasma homocysteine and the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene are risk factors for stroke. 12907815

2003
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Meta-analysis of included studies suggested that TT genotype was obviously associated with increased risk of hemorrhagic str</span>oke (OR (TT versus CC) = 1.84, 95 % CI 1.45-2.34; OR (TT versus CT) = 1.53, 95 % CI 1.23-1.90; OR (TT versus CT/CC) = 1.64, 95 % CI 1.24-2.00) compared with CC or CT genotypes of MTHFR C677T polymorphism. 23184002

2013
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T and A1298C) and Hemorrhagic Stroke in Moroccan Patients. 29555401

2018
dbSNP: rs397507444
rs397507444
MTHFR
0.080 GeneticVariation BEFREE Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T and A1298C) and Hemorrhagic Stroke in Moroccan Patients. 29555401

2018
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Moreover, the 677 C-->T genotype is a strong factor for predisposition to hyperhomocysteinemia and recurrent risk of stroke</span> that might also be prevented with folate supplementation. 10830195

2000
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE MTHFR C677T and A1298C polymorphisms and cerebral stroke in two twin gestations. 21113717

2011
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE MTHFR C677T polymorphism has been studied as a possible risk factor for a variety of common conditions including heart disease, stroke and hypertension. 24192663

2014
dbSNP: rs397507444
rs397507444
MTHFR
0.080 GeneticVariation BEFREE MTHFR C677T and A1298C polymorphisms and cerebral stroke in two twin gestations. 21113717

2011
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE No significant association was found between MTHFR C677T and stroke recurrence or mortality. 19515015

2009