Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800497
rs1800497
0.010 GeneticVariation BEFREE A total of 110 adult patients with ASD (n=61) or ADHD (n=49) with or without a lifetime history of SUD participated in a study in which we genotyped polymorphisms in five known candidate genes for (one of) the disorders, i.e. the 5HTTLPR in SLC6A4/5-HTT, rs1800497 (TaqIA C>T) in DRD2, rs7794745 in CNTNAP2, rs1843809 in TPH2, and rs6565113 in CDH13. 20446882

2010

dbSNP: rs1843809
rs1843809
0.010 GeneticVariation BEFREE A total of 110 adult patients with ASD (n=61) or ADHD (n=49) with or without a lifetime history of SUD participated in a study in which we genotyped polymorphisms in five known candidate genes for (one of) the disorders, i.e. the 5HTTLPR in SLC6A4/5-HTT, rs1800497 (TaqIA C>T) in DRD2, rs7794745 in CNTNAP2, rs1843809 in TPH2, and rs6565113 in CDH13. 20446882

2010

dbSNP: rs6565113
rs6565113
0.010 GeneticVariation BEFREE A total of 110 adult patients with ASD (n=61) or ADHD (n=49) with or without a lifetime history of SUD participated in a study in which we genotyped polymorphisms in five known candidate genes for (one of) the disorders, i.e. the 5HTTLPR in SLC6A4/5-HTT, rs1800497 (TaqIA C>T) in DRD2, rs7794745 in CNTNAP2, rs1843809 in TPH2, and rs6565113 in CDH13. 20446882

2010

dbSNP: rs7794745
rs7794745
0.010 GeneticVariation BEFREE A total of 110 adult patients with ASD (n=61) or ADHD (n=49) with or without a lifetime history of SUD participated in a study in which we genotyped polymorphisms in five known candidate genes for (one of) the disorders, i.e. the 5HTTLPR in SLC6A4/5-HTT, rs1800497 (TaqIA C>T) in DRD2, rs7794745 in CNTNAP2, rs1843809 in TPH2, and rs6565113 in CDH13. 20446882

2010

dbSNP: rs1799971
rs1799971
0.020 GeneticVariation BEFREE Compared to controls, ADHD patients (with and without SUDs) showed significantly increased frequency of the DBH (rs2519152: OR 1.73; CI 1.15-2.59; P=0.008) and the OPRM1 risk genotypes (rs1799971: OR 1.71; CI 1.17-2.50; P=0.006). 22841130

2013

dbSNP: rs2402959
rs2402959
0.010 GeneticVariation BEFREE Single and multiple marker analyses revealed association between two SNPs located at the 3' region of miR-96 (rs2402959 and rs6965643) and ADHD without SUD. 23906647

2013

dbSNP: rs2519152
rs2519152
DBH
0.010 GeneticVariation BEFREE Compared to controls, ADHD patients (with and without SUDs) showed significantly increased frequency of the DBH (rs2519152: OR 1.73; CI 1.15-2.59; P=0.008) and the OPRM1 risk genotypes (rs1799971: OR 1.71; CI 1.17-2.50; P=0.006). 22841130

2013

dbSNP: rs373611092
rs373611092
0.010 GeneticVariation BEFREE One hundred seven methadone maintenance treatment patients, 36 having an ADHD diagnosis, 176 adult patients with ADHD without SUDs, and 500 healthy controls were genotyped for variants in the DRD4 (exon 3 VNTR), DRD5 (upstream VNTR), HTR1B (rs6296), DBH (rs2519152), COMT (rs4680; Val158Met), and OPRM1 (rs1799971; 118A>G) genes. 22841130

2013

dbSNP: rs6965643
rs6965643
0.010 GeneticVariation BEFREE Single and multiple marker analyses revealed association between two SNPs located at the 3' region of miR-96 (rs2402959 and rs6965643) and ADHD without SUD. 23906647

2013

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met. 28913946

2017

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders. 28635556

2017

dbSNP: rs11568817
rs11568817
0.010 GeneticVariation BEFREE As for the comorbidities evaluated, after correction for multiple tests, significant associations were observed for both rs11568817 and rs130058 with substance use disorders (P<sub>corr</sub> = 0.009 and P<sub>corr</sub> = 0.018, respectively) and for rs11568817 with nicotine dependence (P<sub>corr</sub> = 0.025) in men with ADHD. 28923721

2017

dbSNP: rs130058
rs130058
0.010 GeneticVariation BEFREE As for the comorbidities evaluated, after correction for multiple tests, significant associations were observed for both rs11568817 and rs130058 with substance use disorders (P<sub>corr</sub> = 0.009 and P<sub>corr</sub> = 0.018, respectively) and for rs11568817 with nicotine dependence (P<sub>corr</sub> = 0.025) in men with ADHD. 28923721

2017

dbSNP: rs6277
rs6277
0.010 GeneticVariation BEFREE This work has implications for a number of psychiatric conditions in which dopamine signaling and variation in C957T status have been implicated, including schizophrenia and substance use disorders. 28398340

2017

dbSNP: rs1799971
rs1799971
0.020 GeneticVariation BEFREE There were no significant associations observed for <i>DRD2</i> rs1076560 SNP, <i>OPRM1</i> rs1799971 SNP, and combined genotypes of both SNPs in the SUD group. 29881439

2018

dbSNP: rs1076560
rs1076560
0.010 GeneticVariation BEFREE This study is the first study to determine the allele frequency and the genetic association of the <i>DRD2</i> rs1076560 SNP and <i>OPRM1</i> rs1799971 SNP variants in clinically diagnosed patients with SUD from the United Arab Emirates (UAE). 29881439

2018

dbSNP: rs9296158
rs9296158
0.010 GeneticVariation BEFREE Working memory reflects vulnerability to early life adversity as a risk factor for substance use disorder in the FKBP5 cortisol cochaperone polymorphism, rs9296158. 31185043

2019

dbSNP: rs324420
rs324420
0.010 GeneticVariation BEFREE This may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should consider FAAH C385A polymorphism. 31775159

2020