Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057518916
rs1057518916
SCN5A
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1178187217
rs1178187217
DNAH11
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1247665387
rs1247665387
FA2H
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1554430943
rs1554430943
KCNH2
T 0.700 GeneticVariation CLINVAR

dbSNP: rs199473442
rs199473442
KCNQ1
G 0.700 GeneticVariation CLINVAR

dbSNP: rs201943194
rs201943194
DNAH11
T 0.700 CausalMutation CLINVAR

dbSNP: rs543860009
rs543860009
TTN ; TTN-AS1
A 0.700 CausalMutation CLINVAR

dbSNP: rs766265889
rs766265889
TTN ; TTN-AS1
A 0.700 GeneticVariation CLINVAR

dbSNP: rs868064163
rs868064163
ACTL6A
T 0.700 GeneticVariation CLINVAR

dbSNP: rs878854378
rs878854378
TTN ; TTN-AS1
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1254179611
rs1254179611
KCNH2
0.010 GeneticVariation BEFREE Inderal or propanolol (a beta blocker) appears to be effective in preventing arrhythmias and syncope for an LQTS patient with the KCNQ1 L191P mutation. 12442276

2002
dbSNP: rs199473401
rs199473401
KCNQ1
0.010 GeneticVariation BEFREE Inderal or propanolol (a beta blocker) appears to be effective in preventing arrhythmias and syncope for an LQTS patient with the KCNQ1 L191P mutation. 12442276

2002
dbSNP: rs7626962
rs7626962
SCN5A
0.010 GeneticVariation BEFREE Our study shows that mutation S1103Y does exist in the white population, and it is associated with a considerable risk of syncope, ventricular arrhythmia, ventricular fibrillation, and sudden death in this population. 12471205

2002
dbSNP: rs104894485
rs104894485
HCN4
0.010 GeneticVariation BEFREE A missense mutation, D553N, was found in a patient with sinus node dysfunction who showed recurrent syncope, QT prolongation in electrocardiogram, and polymorphic ventricular tachycardia, torsade de pointes. 15123648

2004
dbSNP: rs120074193
rs120074193
KCNQ1
0.010 GeneticVariation BEFREE Although G269S in the KVLQT1 gene was detected in a female with known family history of syncope and sudden cardiac death, no other mutations were found in any of the 14 cases, and no other mutations was found in 200 controls. 16436635

2006
dbSNP: rs104894585
rs104894585
KCNJ2
0.010 GeneticVariation BEFREE In this study, we characterized the KCNJ2 channels with an ATS mutation (T75M) which is associated with cardiac phenotypes of bi-directional ventricular tachycardia, syncope, and QT(c) prolongation. 17582433

2007
dbSNP: rs121434500
rs121434500
SNTA1
0.010 GeneticVariation BEFREE A missense mutation (A390V-SNTA1) was found in a patient with recurrent syncope and markedly prolonged QT interval (QTc, 530 ms). 18591664

2008
dbSNP: rs199473012
rs199473012
KCNH2
0.010 GeneticVariation BEFREE The patient affected by L955V suffered from recurrent syncope (QTc approximately 460 ms), and this mutation led to greatly reduced current and reduced KCNH2 protein in plasma membrane preparations. 18675227

2008
dbSNP: rs199473103
rs199473103
SCN5A
0.010 GeneticVariation BEFREE A missense mutation (A390V-SNTA1) was found in a patient with recurrent syncope and markedly prolonged QT interval (QTc, 530 ms). 18591664

2008
dbSNP: rs554903493
rs554903493
SLCO6A1
0.010 GeneticVariation BEFREE A missense mutation (A390V-SNTA1) was found in a patient with recurrent syncope and markedly prolonged QT interval (QTc, 530 ms). 18591664

2008
dbSNP: rs199473605
rs199473605
SCN5A
0.010 GeneticVariation BEFREE A novel SCN5A missense mutation, V1340I, was identified in a patient with BrS suffering from frequent episodes of polymorphic ventricular tachycardia (VT) and syncope associated with fever. 19648062

2009
dbSNP: rs143149582
rs143149582
KCNQ1
0.010 GeneticVariation BEFREE A novel missense mutation in the KCNQ1 gene, KCNQ1 P320H, was identified in the index patient presenting with recurrent syncope and aborted sudden death triggered by physical stress and swimming. 19540844

2010
dbSNP: rs199473470
rs199473470
KCNQ1
0.010 GeneticVariation BEFREE A novel missense mutation in the KCNQ1 gene, KCNQ1 P320H, was identified in the index patient presenting with recurrent syncope and aborted sudden death triggered by physical stress and swimming. 19540844

2010
dbSNP: rs1805123
rs1805123
KCNH2
0.020 GeneticVariation BEFREE Subgroup analysis showed that the presence of the K897T polymorphism in the LQT2 gene in an affected family was associated with an 11-fold (P=0.001) increase in the risk of recurrent syncope in genotype-negative subjects. 21831960

2011
dbSNP: rs199472730
rs199472730
KCNQ1
0.020 GeneticVariation BEFREE We identified a KCNQ1 missense mutation, KCNQ1 S277L, in a patient presenting with recurrent syncope triggered by emotional stress (QTc=528ms). 21241800

2011