rs33996649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data showed that the PTPN22 R620W polymorphism is a risk factor for TA (CC vs. CT: OR 4.3, p = 0.002, and C vs. T: OR 4.1, p = 0.003); however, the PTPN22 R263Q and - 1123G/C polymorphisms are not associated with this AD.
|
30470857 |
2019 |
rs114202986
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, rs3763288 and rs114202986 in MICA were negatively related to TA either as a whole or in any clinical features.
|
28261975 |
2018 |
rs1205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
T allele of rs1205 in CRP gene was less frequent in TA.
|
29024426 |
2018 |
rs1264457
|
|
|
0.010 |
GeneticVariation |
BEFREE |
sHLA-E level is useful as a biomarker of disease activity and course in TA patients. rs1264457 polymorphism is neither associated with susceptibility nor did it influence sHLA-E levels in TA.
|
28425192 |
2018 |
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA.
|
28438554 |
2018 |
rs3763288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, rs3763288 and rs114202986 in MICA were negatively related to TA either as a whole or in any clinical features.
|
28261975 |
2018 |
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G allele of rs763780 in IL-17F gene was protectively associated against susceptibility to TA.
|
28438554 |
2018 |
rs9366782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicated that rs12524487 in HLA-B/MICA was a genetic risk factor for TA in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
|
28261975 |
2018 |
rs4921492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
rs4921493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
rs60689680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
rs1004819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a trend for IL12A rs582054 and IL23R rs1004819 in association with the TA phenotype was detected.
|
26987707 |
2016 |
rs582054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a trend for IL12A rs582054 and IL23R rs1004819 in association with the TA phenotype was detected.
|
26987707 |
2016 |
rs2836878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
rs104895476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case of infantile Takayasu arteritis with a p.D382E NOD2 mutation: an unusual phenotype of Blau syndrome/early-onset sarcoidosis?
|
22821420 |
2013 |
rs2476601
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This is the first report documenting an association between PTPN22 R620W and TA.
|
30470857 |
2019 |
rs665268
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MLX-Q139R mutation plays a crucial role in the pathogenesis of TAK through promoting inflammasome formation.
|
30354298 |
2018 |
rs56167332
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.
|
26996483 |
2016 |
rs665268
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.
|
26996483 |
2016 |
rs56167332
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also established the genetic association between IL12B and Takayasu arteritis (rs56167332, OR = 1.54, p = 2.18 × 10(-8)).
|
23830517 |
2013 |
rs2476601
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene.
|
18375974 |
2008 |
rs6871626
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common component of IL-12p70 and IL-23.
|
28874185 |
2017 |
rs6871626
|
|
|
0.050 |
GeneticVariation |
BEFREE |
IL12B rs6871626 did not show an association with IBD-TA compared with that with TA without IBD.
|
28449344 |
2017 |
rs6871626
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
rs6871626
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Thus, our study points to potential diagnostic use of SNP rs6871626 for predicting disease severity of TAK, with the goal of genotyping-oriented therapy in the near future.
|
25783557 |
2016 |