|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although other vasculitides, such as giant cell arteritis (GCA) or immunoglobulin A vasculitis, have not benefitted by the great advantage of the large-scale genetic analyses yet, some interesting associations have been recently suggested, such as the classical functional PTPN22 allele rs2476601 (R620W) with GCA.
|
25405820 |
2015 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the non-HLA region, we confirmed a key role for the functional PTPN22 rs2476601 variant and proposed other putative risk loci for GCA involved in Th1, Th17, and Treg cell function.
|
25817017 |
2015 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A meta-analysis, comprising 577 GCA patients and 1153 controls, did not confirm an association between GCA and rs4986790 (OR 1.29, 95% CI 0.86, 1.92, p=0.22).
|
24447403 |
2014 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results suggest that the PTPN22 polymorphism rs2476601/R620W plays an important role in the genetic risk to GCA.
|
23946333 |
2013 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the TLR4 Asp299Gly polymorphism may confer susceptibility to GCA.
|
23065292 |
2013 |
|
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 155 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 210 population-based controls from the same geographical area were genotyped for two coding single nucleotide polymorphisms of TLR4 (Asp299Gly and Thr399Ile) by molecular methods.
|
19646345 |
2010 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The A1298C polymorphism was associated with GCA in East Asians: the FE OR for the allele contrast (C vs. A) was 1.38 (1.18-1.62), and under a recessive model for allele C, OR=1.62 (1.28-2.06).
|
16758123 |
2006 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Using a cohort we have been studying in Linxian since 1985, we examined the relationship between incident ESCC and GCA cancers and three polymorphisms in two genes that code for enzymes that require folate and B(12) as cofactors: methionine synthase reductase (MTRR) A66G and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C.
|
14652285 |
2003 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The MTHFR A1298C polymorphism had no effect on risk of GCA.
|
12433726 |
2002 |
|
rs1883832
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
rs1799969
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, the meta-analysis revealed a significant association between the ICAM-1 G241R R allele and Behcet's disease (BD) (OR = 3.261, 95% CI = 1.653-6.434, p = 0.001), but not giant cell arteritis.
|
27894415 |
2016 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These SNPs included rs4986790 (+896A/G, Asp299Gly) and rs4986791 (+1196C/T) which have been previously studied in GCA.
|
24447403 |
2014 |
|
rs2274223
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association was more prominent for rs2274223 in female (OR = 1.86, 95% CI: 1.49-2.32) and gastric cardia adenocarcinoma (GCA) (OR = 1.71, 95% CI: 1.49-1.95).
|
21427165 |
2011 |
|
rs2274223
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus in genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) that share similar risk factors with SCCHN.
|
21689432 |
2011 |
|
rs1883832
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest a potential implication of the CD40 rs1883832 C/T polymorphism in susceptibility to visual ischemic manifestations in individuals with biopsy-proven GCA.
|
20682661 |
2010 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 155 patients with biopsy-proven GCA who were residents of Reggio Emilia, Italy, and 210 population-based controls from the same geographical area were genotyped for two coding single nucleotide polymorphisms of TLR4 (Asp299Gly and Thr399Ile) by molecular methods.
|
19646345 |
2010 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between the MTHFR C677T and SHMT ( 1 ) C1420T polymorphisms and the risk of ESCC and GCA was demonstrated.
|
17206530 |
2007 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that the MTHFR C677T and MTRR A66G polymorphisms influence the risk of ESCC and GCA in this population.
|
14652285 |
2003 |
|
rs1799969
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings show that G/R 241 polymorphism of ICAM-1 is associated with PMR/GCA susceptibility and confers an increased risk of relapse/recurrence in PMR.
|
10813290 |
2000 |
|
rs10069690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed that CXCR4 rs6430612, TERT rs10069690, and rs2853676 as well as VPS34 rs2162440 are significantly associated with GCA development.
|
30900102 |
2019 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C282Y homozygote men had increased likelihoods of reporting chronic pain (odds ratio [OR] 1.23: 95% confidence interval [CI] 1.05-1.45, p = .01) and diagnoses of polymyalgia rheumatica, compared to common "wild-type" genotype.
|
30657865 |
2019 |
|
rs2162440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the odds of having the VPS34 rs2162440 GA genotype in GCA patients were 1.35 compared with the GG genotype (P = 0.002).
|
30900102 |
2019 |
|
rs2853676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed that CXCR4 rs6430612, TERT rs10069690, and rs2853676 as well as VPS34 rs2162440 are significantly associated with GCA development.
|
30900102 |
2019 |
|
rs6430612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 0.64-fold decreased risk of GCA is associated with the CXCR4 rs6430612 CT genotype compared with the CC genotype (P = 0.002).
|
30900102 |
2019 |
|
rs374039502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, combined analysis of the different sets evidenced a lack of association of the rs374039502 variant with GCA (P = 0.421; OR (95% CI) = 0.92 (0.75-1.13)) and SSc (P = 0.500; OR (95% CI) = 1.05 (0.91-1.22)).
|
30586461 |
2018 |