|
rs1031583860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
XRCC1 Arg280His and Arg194Trp were associated with thyroid cancer in Pakistani population.
|
29552790 |
2019 |
|
rs1143623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs3136558 and rs1143623 in the IL1B gene showed strong correlations with a susceptibility to thyroid cancer among individuals aged >48 years.
|
31499272 |
2019 |
|
rs11674595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analyses revealed significant associations of rs3917225, rs2072472 and rs11674595 with susceptibility to thyroid cancer.
|
31021479 |
2019 |
|
rs12785878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>DHCR7</i> rs12785878 minor allele was associated with thyroid cancer under an additive (OR 1.38, 95% CI 1.15-1.65, <i>p</i> = 0.0004) and codominant (OR 1.88, 95% CI 1.30-2.74, <i>p</i> = 0.0021) model.
|
31357732 |
2019 |
|
rs2060793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants close to genes that encode crucial enzymes for the synthesis (<i>DHCR7</i> rs12785878), metabolism (<i>CYP2R1</i> rs2060793) and degradation (<i>CYP24A1</i> rs6013897) of vitamin D have been associated with serum levels of vitamin D. The aim of this case-control study was to determine the effect of these variants in the vitamin D pathway on the susceptibility to thyroid cancer.
|
31357732 |
2019 |
|
rs2072472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analyses revealed significant associations of rs3917225, rs2072472 and rs11674595 with susceptibility to thyroid cancer.
|
31021479 |
2019 |
|
rs3783521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant associations were detected between IL1A rs3783521 and an increased thyroid cancer risk in our study population (p < 0.05).
|
31499272 |
2019 |
|
rs3917225
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analyses revealed significant associations of rs3917225, rs2072472 and rs11674595 with susceptibility to thyroid cancer.
|
31021479 |
2019 |
|
rs6013897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants close to genes that encode crucial enzymes for the synthesis (<i>DHCR7</i> rs12785878), metabolism (<i>CYP2R1</i> rs2060793) and degradation (<i>CYP24A1</i> rs6013897) of vitamin D have been associated with serum levels of vitamin D. The aim of this case-control study was to determine the effect of these variants in the vitamin D pathway on the susceptibility to thyroid cancer.
|
31357732 |
2019 |
|
rs763538721
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, glycolysis-related enzymes, such as LDHA and PKM2, were upregulated in BRAF V600E </span>mutant thyroid cancer specimens, thereby promoting glycolysis.
|
30768848 |
2019 |
|
rs78929565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals with minor allele of rs789</span>29565 and higher Cd exposure had increased susceptibility to TC.
|
31637582 |
2019 |
|
rs1032006770
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among them, the MET p.N375S and MLH1 p.V384D mutations, each was detected in two cases, and has rarely been found to be involved in thyroid cancer pathogenesis before.
|
28757314 |
2018 |
|
rs1057519736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IDH2 mutations were identified in all six BPTCs (three R172S, two R172T and one R172G), four of which also harboured PIK3CA mutations (two H1047R, one Q546K and one Q546R).
|
29603332 |
2018 |
|
rs10951937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype-environment interaction between each SNP and ionizing radiation.<b>Results:</b> Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: <i>HUS</i> rs2708896, <i>HUS</i> rs10951937, and <i>MGMT</i> rs12769288.
|
29263185 |
2018 |
|
rs1207011218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between CTLA-4 + 49A > G and - 318C > T single-nucleotide polymorphisms and susceptibility to thyroid neoplasm.
|
30078171 |
2018 |
|
rs121913286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IDH2 mutations were identified in all six BPTCs (three R172S, two R172T and one R172G), four of which also harboured PIK3CA mutations (two H1047R, one Q546K and one Q546R).
|
29603332 |
2018 |
|
rs12769288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype-environment interaction between each SNP and ionizing radiation.<b>Results:</b> Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: <i>HUS</i> rs2708896, <i>HUS</i> rs10951937, and <i>MGMT</i> rs12769288.
|
29263185 |
2018 |
|
rs180414
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Major allele homozygote (CC) of rs1136410 and combined genotype (TT+TC) of rs180414 showed a significant association with thyroid cancer risk (OR = 1.30; 95% CI 0.99-1.77; P = 0.05) and (OR = 0.43; 95% CI = 0.27-0.67; P = 0.03).
|
30183716 |
2018 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between CTLA-4 + 49A > G and - 318C > T single-nucleotide polymorphisms and susceptibility to thyroid neoplasm.
|
30078171 |
2018 |
|
rs2708896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype-environment interaction between each SNP and ionizing radiation.<b>Results:</b> Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: <i>HUS</i> rs2708896, <i>HUS</i> rs10951937, and <i>MGMT</i> rs12769288.
|
29263185 |
2018 |
|
rs33917957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among them, the MET p.N375S and MLH1 p.V384D mutations, each was detected in two cases, and has rarely been found to be involved in thyroid cancer pathogenesis before.
|
28757314 |
2018 |
|
rs63750447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among them, the MET p.N375S and MLH1 p.V384D mutations, each was detected in two cases, and has rarely been found to be involved in thyroid cancer pathogenesis before.
|
28757314 |
2018 |
|
rs75076352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC.
|
29436694 |
2018 |
|
rs78201625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Authors showed that a new variant (p.R122W) displayed a minor allele frequency (MAF) significantly higher in FNMTC patients than in controls (7.5 vs 0.73%, p = 0.016) and cosegregated with thyroid cancer in one kindred, thus suggesting the need for the evaluation of its possible pathogenicity in other series.
|
28779995 |
2018 |
|
rs9344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the <i>CCND1</i> rs9344 (G870A) polymorphism and the expression profiles of wild-type <i>CCND1a</i> and shortened oncogenic isoform <i>CCND1b</i> at the mRNA and protein levels in 286 thyroid tumors.
|
30428594 |
2018 |