|
rs7868992
|
|
|
0.810 |
GeneticVariation |
BEFREE |
PCR-directed sequencing was used to evaluate the genetic contributions of three SNPs in COL27A1(rs4979356, rs4979357 and rs7868992) using haplotype relative risk (HRR) and transmission disequilibrium tests (TDT) with a total of 260 Tourette syndrome trios.
|
26235311 |
2015 |
|
rs7868992
|
|
G |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study of Tourette's syndrome.
|
22889924 |
2013 |
|
rs7868992
|
|
G |
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study of Tourette's syndrome.
|
22889924 |
2013 |
|
rs2708146
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs2708146
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Conditional FDR analysis further revealed novel variants significantly associated with TS (p < 8 × 10<sup>-7</sup>) when conditioning on intracranial (rs2708146, q = 0.046; and rs72853320, q = 0.035) and hippocampal (rs1922786, q = 0.001) volumes, respectively.
|
30902966 |
2019 |
|
rs267606861
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Recently, a heterozygous W317X mutation in the histidine decarboxylase gene (HDC) was reported to be responsible for TS in a two-generation pedigree.
|
22095709 |
2012 |
|
rs267606861
|
|
T |
0.710 |
CausalMutation |
CLINVAR |
|
|
|
|
rs10846381
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs117648881
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs12459560
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs13407215
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs150975336
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs1906252
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs191044310
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs2504235
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs4047771
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.
|
30818990 |
2019 |
|
rs11149058
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
|
25158072 |
2015 |
|
rs4271390
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
|
25158072 |
2015 |
|
rs4988462
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
|
25158072 |
2015 |
|
rs191284403
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs193302861
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs9357271
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The frequency of MAFs of the genotyped SNPs was lower in GTS patients with Attention Deficit Hyperactivity Disorder (for rs9357271 and rs9296249, P=0.039 and rs4714156, P=0.040) and higher in GTS patients without comorbidities (for rs9357271 and rs9296249 P=0.021 and rs4714156 P=0.025).
|
24993631 |
2014 |
|
rs9357271
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Variants of the BTB/POZ domain-containing protein 9 gene (BTBD9) (rs4714156, rs9357271, and rs9296249) and the serotonin 5-HT-2C receptor gene (HTR2C) (rs518147 and rs3813929) were reported to be associated with Tourette syndrome (TS) in White population recently.
|
22914617 |
2012 |
|
rs9357271
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We stratified our group of patients with TS according to presence or absence of obsessive-compulsive disorder and/or attention-deficit disorder and found that variants in BTBD9 were strongly associated with TS without obsessive-compulsive disorder (chi(2) = 12.95 [P < .001] for rs9357271).
|
19822783 |
2009 |
|
rs6313
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study suggested that the HTR2A 102T/C and -1438A/G polymorphisms may not be associated with susceptibility to TS, and thus do not play a major role in the development of TS in the Chinese Han population.
|
25858583 |
2016 |