In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10-1.57, <i>p</i> = 0.003; GG vs. GC + CC: OR = 0.69, 95% CI: 0.56-0.85, <i>p</i> < 0.001) and A/O (O/A: OR = 1.34, 95% CI: 1.10-1.64, <i>p</i> = 0.004) were associated with tuberculosis risk in Asians, A/O (AA vs. AO + OO: OR = 0.71, 95% CI: 0.51-0.99, <i>p</i> = 0.041) and rs1800451 (AC vs. AA + CC: OR = 2.70, 95% CI: 1.27-5.74, <i>p</i> = 0.010) were associated with tuberculosis risk in Americans, and rs1800451 (C/A: OR = 0.92, 95% CI: 0.86-0.99, <i>p</i> = 0.035) was associated with tuberculosis risk in Africans.
Polymorphisms of MBL (rs7096206) and MASP-2 (rs2273346 and rs6695096) were associated with the susceptibility of TB, and there were gene-gene interactions among them.
Passive smoking, cooking with solid fuel, and polymorphisms of MBL (rs7096206) and MASP-2 (rs6695096) genes were associated with susceptibility to TB in non-smokers, and there were gene-environment interactions among them.