Gene: ASAP1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4733781
rs4733781
ASAP1
0.740 GeneticVariation BEFREE Our data indicated that the A allele of rs4733781 for the <i>ASAP1</i> gene was in association with a decreased risk of TB. 31089398

2019
dbSNP: rs4733781
rs4733781
ASAP1
0.740 GeneticVariation BEFREE Significant differences of the allelic distribution of rs4733781 and rs1017281 in ASAP1 gene were observed between control group and TB group. 29545860

2018
dbSNP: rs4733781
rs4733781
ASAP1
0.740 GeneticVariation BEFREE A GWAS study has reported that ASAP1 polymorphisms (rs4733781 and rs10956514) were associated with the risk of tuberculosis (TB) in Russians. 27227929

2016
dbSNP: rs4733781
rs4733781
ASAP1
0.740 GeneticVariation BEFREE In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10(-11) for rs4733781; P = 1.0 × 10(-10) for rs10956514). 25774636

2015
dbSNP: rs4733781
rs4733781
ASAP1
A 0.740 GeneticVariation GWASCAT In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10(-11) for rs4733781; P = 1.0 × 10(-10) for rs10956514). 25774636

2015
dbSNP: rs10956514
rs10956514
ASAP1
0.040 GeneticVariation BEFREE Whereas, SNP rs10956514A/G were not associated with TB in western Chinese Han and Tibetan population. 30167433

2018
dbSNP: rs10956514
rs10956514
ASAP1
0.040 GeneticVariation BEFREE We did not find significant association between genetic variants at 8q24 and risk of TB (rs10956514: OR=0.89, 95%CI: 0.72-1.09, P=0.253; rs11774633: OR=0.86, 95%CI: 0.69-1.08, P=0.206). 26964908

2016
dbSNP: rs10956514
rs10956514
ASAP1
0.040 GeneticVariation BEFREE Meta-analysis showed no evidence supporting association between rs10956514 and overall risk for TB. 27227929

2016
dbSNP: rs10956514
rs10956514
ASAP1
0.040 GeneticVariation BEFREE In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10(-11) for rs4733781; P = 1.0 × 10(-10) for rs10956514). 25774636

2015
dbSNP: rs1017281
rs1017281
ASAP1
0.010 GeneticVariation BEFREE Significant differences of the allelic distribution of rs4733781 and rs1017281 in ASAP1 gene were observed between control group and TB group. 29545860

2018
dbSNP: rs11774633
rs11774633
ASAP1
0.010 GeneticVariation BEFREE We did not find significant association between genetic variants at 8q24 and risk of TB (rs10956514: OR=0.89, 95%CI: 0.72-1.09, P=0.253; rs11774633: OR=0.86, 95%CI: 0.69-1.08, P=0.206). 26964908

2016
dbSNP: rs4236749
rs4236749
ASAP1
0.010 GeneticVariation BEFREE Subsequent analysis referring to the genotypes of SNPs in relationship to clinical phenotypes identified that rs4236749 was associated with different serum C-reactive protein levels, suggesting a role of this locus in influencing the inflammatory state of Western Chinese Han patients with TB.Our present data revealed that ASAP1 polymorphisms are unlikely to confer susceptibility to TB in the Western Chinese Han and Tibetan populations, which challenges the promising roles of the ASAP1 gene in the development of TB and highlights the importance of validating the association findings across ethnicities. 27227929

2016