|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
(2) In subgroup analysis based on ethnicity, TLR2 Arg753Gln</span> polymorphism elevates the risk of TB in Asian and Caucasian populations, but not in African or mixed populations.
|
30733958 |
2019 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The R753Q TLR2 polymorphism has been associated with increased incidence of tuberculosis and infections with non-tuberculous mycobacteria in human populations, but the mechanisms by which this polymorphism affects TLR2 signaling are unclear.
|
28442574 |
2017 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This case-control study aims to determine the influence of TLR2 (Arg753Gln and Arg677Trp) polymorphisms on the susceptibility to develop pulmonary or peritoneal TB.
|
28332241 |
2017 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also detected an association of TLR2 gene with tuberculosis (rs5743708; 3.19 [2.03-5.02]).
|
26524966 |
2015 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs5743708 gene polymorphism in the TLR2 gene contributes to the risk of tuberculosis disease</span>.
|
26617949 |
2015 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis provides evidence that the TLR2 gene Arg753Gln polymorphism is a risk factor to TB, especially in Asian populations.
|
26220088 |
2015 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TLR2 rs5743708 subgroup analysis identified the A allele to increase susceptibility to TB in the Asian ethnic group, while conferring protection in the Hispanic group.
|
26430737 |
2015 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The meta-analysis indicated that TLR2 G2258A is associated with increased TB risk, especially in Asians and Europeans.
|
23691034 |
2013 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that the Arg753Gln polymorphism of the TLR-2 gene influences the speed of progression from infection to TB disease in children.
|
21320563 |
2011 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls.
|
20002809 |
2010 |
|
rs5743708
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the present data suggest that the arginine to glutamine substitution at residue 753 polymorphism of the Toll-like receptor 2 gene influences the risk of developing tuberculosis.
|
14979495 |
2004 |
|
rs121917864
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Differences in the genotype frequencies of TLR2 Arg677Trp polymorphisms between patients with pulmonary or peritoneal TB and healthy controls were not detected.
|
28332241 |
2017 |
|
rs121917864
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls.
|
20002809 |
2010 |
|
rs3804099
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also found that individuals with the C allele of TLR-2 T597C allele were more likely to have tuberculosis caused by the East-Asian/Beijing genotype (OR = 1.57 [95% C.I.1.15-2.15]) than other individuals.
|
18369480 |
2008 |
|
rs3804099
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results demonstrate a strong association of TLR2 SNP T597C with the development of TBM and miliary TB and indicate that TLR2 influences the dissemination of M. tuberculosis.
|
17554342 |
2007 |
|
rs3804100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An increased risk of TB was found for individuals with the TLR2 rs3804100 CC and the TLR9 rs352139 GA and GG genotypes, while decreased risk was identified for those with the AG genotype of TLR1 rs4833095.
|
26430737 |
2015 |
|
rs5743704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data, in combination with a report by others show that the TLR2-P631H allele could be associated with protection to meningococcal meningitis, suggest that by dominantly inhibiting the response of cells important in the immune response this mutant might confer either protection or susceptibility to meningitis or tuberculosis, respectively.
|
20500688 |
2010 |
|
rs1816702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multilocus analyses between polymorphisms in SLC11A1 and 11 TB candidate genes detected interactions between SLC11A1 and inducible nitric oxide synthase (NOS2A) in Caucasians (rs3731863 [SLC11A1] x rs8073782 [NOS2A], P = 0.009; rs3731863 [SLC11A1] x rs17722851 [NOS2A], P = 0.007) and toll-like receptor 2 (TLR2) in African-Americans (rs3731865 [SLC11A1] x rs1816702, P = 0.005).
|
19723394 |
2009 |