| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.100 | GeneticVariation | BEFREE | We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. | 31721892 | 2019 |
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0.100 | GeneticVariation | BEFREE | Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity. | 26803486 | 2016 |
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0.100 | GeneticVariation | BEFREE | Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. | 26813412 | 2016 |
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0.100 | GeneticVariation | BEFREE | Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. | 24555772 | 2014 |
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0.100 | GeneticVariation | BEFREE | Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder. | 23618651 | 2013 |
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0.100 | GeneticVariation | BEFREE | Responses to venlafaxine treatment in major depressive disorder were stratified by COMT genotypes (Val158Met, rs4680) in a randomized, double-blind, placebo-controlled clinical trial. | 23706899 | 2013 |
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0.100 | GeneticVariation | BEFREE | Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). | 21600957 | 2011 |
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0.100 | GeneticVariation | BEFREE | This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder. | 19520435 | 2010 |
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0.100 | GeneticVariation | BEFREE | In the present study, the effect of COMT val158met on response to electroconvulsive therapy (ECT) was analyzed in a sample of 104 Caucasian patients (f = 71, m = 33) with pharmacologically treatment-resistant Major Depression. | 19309019 | 2010 |
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0.100 | GeneticVariation | BEFREE | In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. | 17522626 | 2008 |
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0.100 | GeneticVariation | BEFREE | Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. | 15583702 | 2005 |