|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
|
rs1048101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the SNPs within ADRA1A [rs10</span>48101 (T>C)], NPY [rs16476 (A>C), rs16148 (T>C)], as well as ADRB1 [rs28365031 (A>G)] all appeared to predict the prognosis of cervical vertigo in a relatively accurate way (all P < .05).
|
29197114 |
2018 |
|
rs1163944538
|
|
GA |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs121908216
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs121912683
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1352010373
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs144948296
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs151344517
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Missense mutations in the AFG3L2 proteolytic domain account for ∼1.5% of European autosomal dominant cerebellar ataxias.
|
20725928 |
2010 |
|
rs1555735545
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs16148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the SNPs within ADRA1A [rs1048101 (T>C)], NPY [rs16476 (A>C), rs16148 (T>C)], as well as ADRB1 [rs28365031 (A>G)] all appeared to predict the prognosis of cervical vertigo in a relatively accurate way (all P < .05).
|
29197114 |
2018 |
|
rs16476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the SNPs within ADRA1A [rs1048101 (T>C)], NPY [rs16476 (A>C), rs16148 (T>C)], as well as ADRB1 [rs28365031 (A>G)] all appeared to predict the prognosis of cervical vertigo in a relatively accurate way (all P < .05).
|
29197114 |
2018 |
|
rs16979956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury.
|
24860816 |
2014 |
|
rs1783901
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the SNPs rs1939012 and rs1783901 may play a potential role of gene regulation and/or epistasis in a complex etiology of vertigo.
|
30300896 |
2018 |
|
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
OPRM1-A118G polymorphism (A > G) is associated with a reduced risk of postoperative vomiting, but not nausea, pruritus and dizziness.
|
30323865 |
2018 |
|
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, the combined genotype of CYP3A4*18B and OPRM1 A118G may affect fentanyl doses administered for pain control, but not postoperative nausea, vomiting and dizziness.
|
23313934 |
2013 |
|
rs1939012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the SNPs rs1939012 and rs1783901 may play a potential role of gene regulation and/or epistasis in a complex etiology of vertigo.
|
30300896 |
2018 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
|
rs2053044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, the severity of cervical vertigo was classified according to the JOA scoring, and the recovery rate (RR) of cervical vertigo was calculated in light of the formula as: [Formula: see text] RESULTS: The SNPs within ADRA1A [rs1048101 (T>C) and rs3802241 (C>T)], NPY [rs16476 (A>C), rs16148 (T>C), and rs5574 (C>T)], ADRB1 [rs28365031 (A>G)] and ADRB2 [rs2053044 (A>G)] were all significantly associated with regulated risk of cervical vertigo (all P < .05).
|
29197114 |
2018 |
|
rs2304297
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor alleles of three SNPs in CHRNA6 (rs7812298, rs2304297, rs7828365) were associated with a decreased probability of dizziness (OR(95% CI)=0.54 (0.36, 0.81), 0.59 (0.40, 0.86) and 0.58 (0.36, 0.95), respectively), while one SNP in each of three other genes (rs3743077 (CHRNA3), rs755204 (CHRNA4), rs7178176 (CHRNA7)) was associated with an increased probability of dizziness (OR(95% CI)=1.40 (1.02, 1.90), 1.85 (1.05, 3.27) and 1.51 (1.06, 2.15), respectively).
|
24119711 |
2014 |
|
rs28365031
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the SNPs within ADRA1A [rs1048101 (T>C)], NPY [rs16476 (A>C), rs16148 (T>C)], as well as ADRB1 [rs28365031 (A>G)] all appeared to predict the prognosis of cervical vertigo in a relatively accurate way (all P < .05).
|
29197114 |
2018 |
|
rs28937900
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs35697037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms.
|
24860816 |
2014 |
|
rs3743077
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor alleles of three SNPs in CHRNA6 (rs7812298, rs2304297, rs7828365) were associated with a decreased probability of dizziness (OR(95% CI)=0.54 (0.36, 0.81), 0.59 (0.40, 0.86) and 0.58 (0.36, 0.95), respectively), while one SNP in each of three other genes (rs3743077 (CHRNA3), rs755204 (CHRNA4), rs7178176 (CHRNA7)) was associated with an increased probability of dizziness (OR(95% CI)=1.40 (1.02, 1.90), 1.85 (1.05, 3.27) and 1.51 (1.06, 2.15), respectively).
|
24119711 |
2014 |
|
rs3802241
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, the severity of cervical vertigo was classified according to the JOA scoring, and the recovery rate (RR) of cervical vertigo was calculated in light of the formula as: [Formula: see text] RESULTS: The SNPs within ADRA1A [rs1048101 (T>C) and rs3802241 (C>T)], NPY [rs16476 (A>C), rs16148 (T>C), and rs5574 (C>T)], ADRB1 [rs28365031 (A>G)] and ADRB2 [rs2053044 (A>G)] were all significantly associated with regulated risk of cervical vertigo (all P < .05).
|
29197114 |
2018 |
|
rs397507478
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|