|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results showed a significant association between homozygous MTHFR c.677C>T variant and T allele frequencies and vitamin B12 deficiency in the Jordanian population.
|
30581350 |
2018 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Logistic regression analysis results revealed that the <i>MTHFR</i> C677T genotype (TT vs. CT and CC) and vitamin B12 deficiency were risk factors for SCD.
|
30687218 |
2018 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Among these three factors, folate deficiency had the greatest contribution to the serum tHcy concentration, followed by (in order of decreasing effect) MTHFR C677T and vitamin B12 deficiency.
|
28094233 |
2017 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
One of the plausible reasons for susceptibility of individuals with MTHFR C677T in the studied population to various disorders is the high frequency of hyperhomocysteinemia and vitamin B12 deficiency in the 'healthy population'.
|
21878957 |
2012 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome.
|
22084937 |
2012 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
High frequency of vitamin B12 deficiency in asymptomatic individuals homozygous to MTHFR C677T mutation is associated with endothelial dysfunction and homocysteinemia.
|
17449548 |
2007 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Hyperhomocysteinemia, a risk factor for thrombosis, recurrent miscarriages, and osteoporosis, might derive from acquired folate and vitamin B 12 deficiencies and from a C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) gene.
|
15952099 |
2005 |
|
rs1217691063
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We report the lack of megaloblastic anaemia in a patient with severe methionine synthase deficiency who is also homozygous for C677T in MTHFR, hypothesize that the MTHFR polymorphism protects the patient against anaemia and speculate that homozygosity for MTHFR C677T could cause the dissociation between haematological and neurological disease seen in some patients with vitamin B12 deficiency.
|
9453374 |
1997 |