rs9514828
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In multivariate Cox-regression analysis, rs3742330 proved to be an independent predictor for OS, together with the commonly used International Prognostic Index (IPI) and BAFF rs9514828, another SNP we have previously reported to be associated with TCL survival, with hazard ratios (HRs) for patient death rate of 8.956 (95% CI, 1.210 to 66.318; p = 0.032) for the GA genotype and 10.145 (95% CI, 1.371 to 75.084; p = 0.023) for the AA genotype.
|
23251602 |
2012 |
rs9514828
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that BAFF rs9514828 polymorphism was significantly associated with TCL survival.
|
22338013 |
2012 |
rs753716491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma.
|
31527657 |
2019 |
rs753861648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma.
|
31527657 |
2019 |
rs145036301
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through exome sequencing of ENKTL tumor-normal samples, we have identified a hotspot mutation (c.419T>C) in the evolutionarily conserved signaling intermediate in Toll pathway (ECSIT) gene, encoding a V140A variant of ECSIT.
|
29291352 |
2018 |
rs752317734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through exome sequencing of ENKTL tumor-normal samples, we have identified a hotspot mutation (c.419T>C) in the evolutionarily conserved signaling intermediate in Toll pathway (ECSIT) gene, encoding a V140A variant of ECSIT.
|
29291352 |
2018 |
rs2835931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three associations were located next to non-coding RNA genes. rs2660852 flanked 5'UTR of LTA4H (leukotriene A4 hydrolase), rs477145 was intronic to TIAM1 (T-cell lymphoma invasion and metastases) and rs2835931 was intronic to KCNJ6 (potassium channel, inwardly rectifying subfamily J, member 6).
|
26959888 |
2016 |
rs477145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three associations were located next to non-coding RNA genes. rs2660852 flanked 5'UTR of LTA4H (leukotriene A4 hydrolase), rs477145 was intronic to TIAM1 (T-cell lymphoma invasion and metastases) and rs2835931 was intronic to KCNJ6 (potassium channel, inwardly rectifying subfamily J, member 6).
|
26959888 |
2016 |
rs745738344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study.
|
26108796 |
2015 |
rs938448224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
STAT5B N642H is particularly frequent in all forms of γδ-T-cell lymphomas.
|
25586472 |
2015 |
rs13181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma.
|
23619945 |
2013 |
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL10 rs1800896 was associated with B cell lymphoma [per-allele odds ratio (OR) = 1.25, 95 % confidence interval (CI) 1.08-1.45; p trend = 0.003], specifically diffuse large B cell lymphoma (DLBCL) (per-allele OR = 1.29, 95 % CI 1.08-1.53; p trend = 0.004), as well as T cell lymphoma (per-allele OR = 1.44, 95 % CI 1.13-1.82; p trend = 0.003).
|
23640160 |
2013 |
rs1801195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma.
|
23619945 |
2013 |
rs3742330
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In multivariate Cox-regression analysis, rs3742330 proved to be an independent predictor for OS, together with the commonly used International Prognostic Index (IPI) and BAFF rs9514828, another SNP we have previously reported to be associated with TCL survival, with hazard ratios (HRs) for patient death rate of 8.956 (95% CI, 1.210 to 66.318; p = 0.032) for the GA genotype and 10.145 (95% CI, 1.371 to 75.084; p = 0.023) for the AA genotype.
|
23251602 |
2012 |
rs1494555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant interaction with BMI was only observed for IFNGR2 (rs9808753 P(forinteraction) = .034) and IL7R (rs1494555 P(forinteraction) = .016) for NHL overall; IL7R (rs1494555 P(forinteraction) = .016) and TNF (1799724 P(forinteraction) = .031) for B-cell lymphoma; and IL5 (rs2069812 P(forinteraction) = .034) for T-cell lymphoma.
|
20952689 |
2011 |
rs2069812
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant interaction with BMI was only observed for IFNGR2 (rs9808753 P(forinteraction) = .034) and IL7R (rs1494555 P(forinteraction) = .016) for NHL overall; IL7R (rs1494555 P(forinteraction) = .016) and TNF (1799724 P(forinteraction) = .031) for B-cell lymphoma; and IL5 (rs2069812 P(forinteraction) = .034) for T-cell lymphoma.
|
20952689 |
2011 |
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Possible heterogeneity in effects of UVR exposure on T-cell lymphoma risk by VDR rs731236 genotype merits further investigation.
|
21076051 |
2011 |
rs9808753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant interaction with BMI was only observed for IFNGR2 (rs9808753 P(forinteraction) = .034) and IL7R (rs1494555 P(forinteraction) = .016) for NHL overall; IL7R (rs1494555 P(forinteraction) = .016) and TNF (1799724 P(forinteraction) = .031) for B-cell lymphoma; and IL5 (rs2069812 P(forinteraction) = .034) for T-cell lymphoma.
|
20952689 |
2011 |
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87).
|
20087644 |
2010 |
rs1048943
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CYP1A1 rs1048943 AG genotype and the combined AG/GG genotypes were associated with increased risk of NHL (OR(AG) = 1.28, 95% CI = 1.07-1.54; OR(AG/GG) = 1.26, 95% CI = 1.06-1.51) and DLBCL (OR(AG) = 1.32, 95% CI = 1.04-1.66; OR(AG/GG) = 1.30, 95% CI = 1.03-1.63), but not T-cell lymphoma.
|
19899130 |
2009 |
rs1442744764
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected a nonsense mutation, C7249T (resulting in Q2417X, where X is a termination codon) in the PEST domain of NOTCH1 in an ATL patient and detected a 3-bp deletion (positions 7234-7236) that resulted in deletion of a proline codon at codon 2412 in the PEST domain of NOTCH1 in a patient with a T-NHL, peripheral T-cell lymphoma-unspecified (PTCL-u).
|
17483057 |
2007 |
rs61733010
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, individuals variant homozygous for the CYBA (Ex4 + 11C > T) SNP had a 1.6-fold (95% CI = 1.1-2.4, P = 0.019) increased risk of NHL that was particularly pronounced for T-cell lymphoma (OR = 3.5, 95% CI = 1.3-9.6, P = 0.013), but was also associated with non-significant increased risks for each of the common B-cell histologies.
|
17149600 |
2007 |
rs758837678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, individuals variant homozygous for the CYBA (Ex4 + 11C > T) SNP had a 1.6-fold (95% CI = 1.1-2.4, P = 0.019) increased risk of NHL that was particularly pronounced for T-cell lymphoma (OR = 3.5, 95% CI = 1.3-9.6, P = 0.013), but was also associated with non-significant increased risks for each of the common B-cell histologies.
|
17149600 |
2007 |
rs17655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, ERCC5 Asp1104His was associated with increased risk of NHL overall (OR: 1.46; 95% CI: 1.13-1.88; P=0.004), DLBCL (OR: 1.44; 95% CI: 0.99-2.09; P=0.058), and also T cell lymphoma.
|
16738949 |
2006 |
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The numbers of cases of particular subtypes were rather small for stable estimates, but we noted that the PON1 L55M AA allele, associated with slightly increased risk of non-Hodgkin's lymphoma (variant homozygotes OR, 1.36; 95% CI, 0.96-1.95), was most strongly associated with follicular non-Hodgkin's lymphoma and T-cell lymphoma, with ORs for variant homozygotes of 2.12 and 2.93, respectively.
|
16985026 |
2006 |