|
rs1157200929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
|
rs121913254
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A somatic activating Q61K mutation was found on exon 3 of the NRAS gene in both AHL and PTCL, NOS.
|
30085957 |
2019 |
|
rs35631544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
|
rs572432356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
|
rs752626029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
|
rs1162844242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
They include the V600E BRAF mutation in hairy cell leukemia, the L265P MYD88 mutation in Waldenström macroglobulinemia, the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I STAT3 mutations in T-cell large granular lymphocytic leukemia.
|
24689848 |
2014 |
|
rs1353428252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These analyses identified highly recurrent epigenetic factor mutations in TET2, DNMT3A and IDH2 as well as a new highly prevalent RHOA mutation encoding a p.Gly17Val alteration present in 22 of 35 (67%) angioimmunoblastic T cell lymphoma (AITL) samples and in 8 of 44 (18%) PTCL, not otherwise specified (PTCL-NOS) samples.
|
24413734 |
2014 |
|
rs16917496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of rs16917496 with NHL survival was further identified in the peripheral T cell lymphoma (pTCL) subtype of NHL at borderline statistically significant levels (P = 0.069).
|
25343552 |
2014 |
|
rs121912654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single missense mutation at codon 157 (Val to Phe) in exon 5 and at codon 273 (Arg to Pro) in exon 8 was found respectively in 2 DLBLs and in one peripheral T-cell lymphoma (unspecified).
|
17609875 |
2007 |
|
rs28934576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single missense mutation at codon 157 (Val to Phe) in exon 5 and at codon 273 (Arg to Pro) in exon 8 was found respectively in 2 DLBLs and in one peripheral T-cell lymphoma (unspecified).
|
17609875 |
2007 |