| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.080 | GeneticVariation | BEFREE | Stratified analysis was applied for INHA 769G>A by ethnicity; a significant association with POF was only found in the Asian subgroup (allelic frequency: OR 8.89, 95% CI 2.1-5.52; p=0.004). | 25445105 | 2014 |
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0.080 | GeneticVariation | BEFREE | The INHα -124A/G, -16C/T, 679G/A, and 769G/A polymorphisms were analyzed in 52 women with POF and 55 normal healthy women using polymerase chain reaction-restriction enzyme fragment length polymorphism analysis. | 21785376 | 2011 |
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0.080 | GeneticVariation | BEFREE | Although the reduction of inhibin B bioactivity by the INHA G769A mutation is clearly not the only cause, evidence suggests that this change may serve as a susceptibility factor, increasing the likelihood of POF. | 19752047 | 2010 |
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0.080 | GeneticVariation | BEFREE | The meta-analysis showed significant heterogeneity among the studies (P(Q) = 0.01, I(2) = 74%) and lack of evidence that carriers of the G769A variant confer risk of POF: OR = 1.38 (0.48-3.94). | 19542176 | 2009 |
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0.080 | GeneticVariation | BEFREE | This study supports the hypothesis that the INHA 769G>A variant may increase susceptibility to POF with impaired inhibin B bioactivity and provides insight into the complex aetiology of POF. | 17933751 | 2007 |
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0.080 | GeneticVariation | BEFREE | Our results indicate that -16C>T and 769G>A variants in INHalpha gene may not be associated to POF disease. | 16396934 | 2006 |
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0.080 | GeneticVariation | BEFREE | G769A variation of INHalpha is rare in Korea women with POF. | 15227735 | 2004 |
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0.080 | GeneticVariation | BEFREE | The analysis of pedigrees showing the inheritance of the 769G-->A mutation and POF strengthens the concept of the disease heterogeneity, since the POF phenotype was not always associated with the mutation. | 12093833 | 2002 |