rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This study provides a better understanding on the neurobiological mechanisms that may underlie risk of addiction development in carriers of the A118G SNP in <i>OPRM1</i><b>SIGNIFICANCE STATEMENT</b> The pandemic of opioid drug abuse is associated with many socioeconomic burdens.
|
31109961 |
2019 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We conclude that rs1799971 contributes to mechanisms of addiction liability that are shared across different addictive substances.
|
26392368 |
2016 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The mu-opioid receptor (OPRM1) A118G polymorphism has been associated with decreased analgesic effects of opioids and predisposition to addiction.
|
23405975 |
2013 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The nonsynonymous OPRM1 rs1799971 might be a risk factor for addiction to opioids or heroin in an Asian population.
|
23651028 |
2013 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population.
|
22138325 |
2012 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Previous reports on the functional effects (i.e., gain or loss of function), and phenotypic outcomes (e.g., changes in addiction vulnerability and stress response) of a commonly occurring functional single nucleotide polymorphism (SNP) of the mu-opioid receptor (OPRM1 A118G) have been inconsistent.
|
21912675 |
2011 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction.
|
19891732 |
2010 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To clarify the functional mechanisms linking the OPRM1 A118G SNP to addiction and analgesia phenotypes, we derived a mouse model possessing the equivalent nucleotide/amino acid substitution in the Oprm1 gene.
|
19528658 |
2009 |
rs1799971
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |