Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Associations of methylenetetrahydrofolate reductase C677T genotype with blood pressure levels in Chinese population with essential hypertension. 29436860

2018

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This study suggests that both tHcy and the MTHFR C677T gene polymorphism may be important determinants of the incidence of dyslipidemia in Chinese patients with essential hypertension. 26442927

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city. 27780089

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon. 27051013

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Benazepril may cause an increase in plasma Hcy levels among patients with hypertension with low baseline Hcy levels, while effect modification by MTHFR C677T genotypes on the changes in Hcy levels in response to benazepril was not significant among patients with essential hypertension. 25550183

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This meta-analysis supports that MTHFR C677T polymorphism plays a role in developing EH. 25458833

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE There was no significant association between MTHFR C677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension. 20669348

2010

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE No significant association between MTHFR C677T genotypes and changes in Hcy levels in response to antihypertensive was observed in EH patients. 18200034

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The TT genotype of the 677C/T MTHFR polymorphism is associated with EH and CAD. 18068006

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Plasma homocysteine levels in individuals with essential hypertension is affected by the MTHFR 677C --> T polymorphism. 16280279

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Comparison of C677T allele frequencies revealed a higher proportion of the mutant allele (T) in the EH group (40%) compared to unaffected controls (34%) (p=0.07). 15750260

2004