Chinese patients with essential hypertension were treated with the β-blocker metoprolol and followed up for 12 weeks. xTAG® liquid-chip technology was used for CYP2D6 100 C > T and ADRB1 1165G > C genotyping.
Our goal was to determine whether the polymorphisms Arg389Gly (rs1801253) and Ser49Gly (rs1801252) of the ADRB1 gene were associated with essential hypertension in Chinese.
Our findings show that the Arg389Gly polymorphism of the ADRB1 gene confers higher risk of left ventricular hypertrophy in human essential hypertension.