| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.090 | GeneticVariation | BEFREE | Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471). | 26335431 | 2015 |
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0.090 | GeneticVariation | BEFREE | We attempted to evaluate the risk of -217G>A, -152G>A, -20A>C, -6G>A, T174M, M235T and 15241A>G polymorphisms at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to EHT. | 22570327 | 2012 |
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0.090 | GeneticVariation | BEFREE | Gender-related association of AGT gene variants (M235T and T174M) with essential hypertension--a case-control study. | 22148914 | 2012 |
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0.090 | GeneticVariation | BEFREE | Several studies in different populations link Threonine instead of methionine at position 235 (M235T) and Methinine instead of threonine at position 174 (T174M) polymorphisms with essential hypertension. | 18404605 | 2008 |
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0.090 | GeneticVariation | BEFREE | An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. | 12037699 | 2002 |
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0.090 | GeneticVariation | BEFREE | This study shows that M235T and T174M variants are not associated either with essential hypertension or with target organ damage in a Spanish sample. | 9607382 | 1998 |
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0.090 | GeneticVariation | BEFREE | The molecular variant M235T, but not T174M, of the AGT gene is associated significantly with essential hypertension in this Taiwanese population. | 9218179 | 1997 |
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0.090 | GeneticVariation | BEFREE | Using this method, the distribution of two variants of the AGT gene, M235T and T174M, was determined in 80 patients with essential hypertension (EHT) and 100 normotensive controls (control). | 7852920 | 1995 |
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0.090 | GeneticVariation | BEFREE | Two molecular variants of the angiotensinogen gene, one encoding threonine instead of methionine at position 235 (M235T) and the other encoding methionine rather than threonine at position 174 (T174M), were also tested for possible association with essential hypertension. | 8177268 | 1994 |