|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death.
|
28067546 |
2017 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, the present meta-analysis indicated the GNB3 C825T polymorphism is related to increased EH exclusively in Caucasians.
|
28540932 |
2017 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The GNB3 C825T splice variant is associated with the DBP-lowering effect of telmisartan but not amlodipine in Chinese EH patients.
|
26712426 |
2016 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis results suggest that the GNB3-C825T polymorphism is associated with risk of EH in the overall population, the Caucasians and the Chinese.
|
24346074 |
2013 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant association identified between GNB3-C825T polymorphism and EH in Han Chinese population.
|
22714918 |
2012 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
G-protein beta 3 subunit (GNB3) C825T (rs5443) single nucleotide polymorphism (SNP) has been implicated as a risk factor for essential hypertension in the general population.
|
19811352 |
2009 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls.
|
17278960 |
2007 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Case-control association analysis showed a significant association between EH and both the ALDH2 (Lys487Glu) and GNB3 (C825T) variants.
|
17785925 |
2007 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans.
|
17066084 |
2007 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
GNB3 C825T and ACE I/D polymorphisms on the sodium-proton exchanger and the prevalence of essential hypertension in males.
|
16314202 |
2006 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
GNB3 825 C>T is likely to be a significant risk factor for LVH but not for EH in the Emirati population, thereby strengthening the view that LVH is genetically a separate clinical entity.
|
15614196 |
2005 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate.
|
15042113 |
2004 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension.
|
15200440 |
2004 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity.
|
12730030 |
2003 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G-protein beta3 subunit (GNB3) C825T polymorphism was detected through a classical candidate gene approach using cell lines with enhanced G-protein activation from patients with essential hypertension.
|
12530935 |
2003 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been described in cells from patients with essential hypertension and enhanced Na+/H+ exchange activity.
|
12113397 |
2002 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension.
|
12011775 |
2002 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the C825T polymorphism of the G protein beta(3)-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy.
|
11230366 |
2001 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
GNB3 825C-->T is not associated with the phenotype of hypertensive crisis in patients suffering from essential hypertension.
|
11008983 |
2000 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In 34 white patients with established mild to moderate essential hypertension (World Health Organization stage I or II, mean age 52 +/- 9 years) genotype analysis of GNB3 C825T polymorphism, insertion/deletion polymorphism of the ACE gene and 1166 A/C polymorphism of the AT1 receptor gene was performed.
|
10526907 |
1999 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the 825C/T polymorphism of the GNB3 gene did not contribute in any important way to the risk of essential hypertension or MI in these studies.
|
10334807 |
1999 |