|
rs13306026
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs13333226
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations of methylenetetrahydrofolate reductase C677T genotype with blood pressure levels in Chinese population with essential hypertension.
|
29436860 |
2018 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that both tHcy and the MTHFR C677T gene polymorphism may be important determinants of the incidence of dyslipidemia in Chinese patients with essential hypertension.
|
26442927 |
2017 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further subgroup analyses yielded similar positive results for G894T SNP in essential hypertension, gestational hypertension, and Asian ethnicity, and that for T-786C SNP in essential hypertension and Asian population.
|
28287883 |
2017 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This association remained statistically significant after the multivariate analysis (odds ratio 2.548, P = .02).The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with EH risk in our population.
|
29049185 |
2017 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This work showed that the interaction between the ADD1 rs4961 variant, obesity, and the presence of diabetes increased the susceptibility to EH four-fold.
|
28872890 |
2017 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death.
|
28067546 |
2017 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, the present meta-analysis indicated the GNB3 C825T polymorphism is related to increased EH exclusively in Caucasians.
|
28540932 |
2017 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city.
|
27780089 |
2016 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between the MTHFR C677T gene polymorphism and essential hypertension in South West Cameroon.
|
27051013 |
2016 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Benazepril may cause an increase in plasma Hcy levels among patients with hypertension with low baseline Hcy levels, while effect modification by MTHFR C677T genotypes on the changes in Hcy levels in response to benazepril was not significant among patients with essential hypertension.
|
25550183 |
2016 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The GNB3 C825T splice variant is associated with the DBP-lowering effect of telmisartan but not amlodipine in Chinese EH patients.
|
26712426 |
2016 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Impact of obesity and nitric oxide synthase gene G894T polymorphism on essential hypertension.
|
26579574 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We explored the associations of the G894T polymorphism with 24-h ambulatory blood pressure, left ventricular mass (LVM), carotid intima media thickness (cIMT), urinary albumin excretion, oxidative stress and inflammatory parameters in 126 children with newly diagnosed PH and in 83 healthy children.
|
26227630 |
2015 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present case-control study failed to show significant association of G894T variant with EH in northern Han Chinese.
|
24846690 |
2015 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we observed a significant association between rs4961 and EH under the dominant model after Bonferroni correction when adjusting for confounding factors in the entire sample (odds ratio (OR)=0.64, 95% confidence interval (CI)=0.50-0.83, P=0.001).
|
25567773 |
2015 |
|
rs4961
|
|
|
0.100 |
GeneticVariation |
BEFREE |
All studies analyzing the association between ADD1 Gly460Trp polymorphism and EH risk were included.
|
26042478 |
2015 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis supports that MTHFR C677T polymorphism plays a role in developing EH.
|
25458833 |
2014 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India.
|
24860821 |
2014 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India.
|
24860821 |
2014 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population.
|
23613274 |
2013 |
|
rs5443
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis results suggest that the GNB3-C825T polymorphism is associated with risk of EH in the overall population, the Caucasians and the Chinese.
|
24346074 |
2013 |