|
rs2476601
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
|
26362759 |
2016 |
|
rs2476601
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A significant association was noted between the R620W variant (rs2476601) and IIM (corrected P [Pcorr]=0.0009 versus controls), and specifically with the clinical subgroup of PM (Pcorr=0.003 versus controls).
|
18821667 |
2008 |
|
rs3094013
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
|
26362759 |
2016 |
|
rs13277113
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
|
rs13277113
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism in C8orf13-BLK (dbSNP ID: rs13277113) was investigated in the Japanese population using a TaqMan assay in 283 polymyositis patients, 194 dermatomyositis patients, and 656 control subjects.
|
24632671 |
2014 |
|
rs10758593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs7020673 and rs10758593 were associated with PM</span> in both additive and dominant models (p < 0.05); however, these observed associations were not apparent after Bonferroni correction.
|
28846454 |
2017 |
|
rs10814916
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether SNPs in GLIS3 (rs7020673, rs10758593, and rs10814916) and TYK2 (rs280519, rs2304256, rs17000730, and rs280501) were associated with an increase in susceptibility to DM/PM in a Chinese Han population.
|
28846454 |
2017 |
|
rs17000730
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether SNPs in GLIS3 (rs7020673, rs10758593, and rs10814916) and TYK2 (rs280519, rs2304256, rs17000730, and rs280501) were associated with an increase in susceptibility to DM/PM in a Chinese Han population.
|
28846454 |
2017 |
|
rs280501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether SNPs in GLIS3 (rs7020673, rs10758593, and rs10814916) and TYK2 (rs280519, rs2304256, rs17000730, and rs280501) were associated with an increase in susceptibility to DM/PM in a Chinese Han population.
|
28846454 |
2017 |
|
rs7020673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs7020673 and rs10758593 were associated with PM in both additive and dominant models (p < 0.05); however, these observed associations were not apparent after Bonferroni correction.
|
28846454 |
2017 |
|
rs10069690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system.
|
26320593 |
2015 |
|
rs11171739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system.
|
26320593 |
2015 |
|
rs2248932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FAM167A-BLK single nucleotide polymorphisms (SNPs) rs2736340, rs7812879, rs13277113, rs2618479, rs2254546 and rs2248932 were analyzed in polymyositis (PM) patients (n = 310), DM patients (n = 535) and 968 ethnically matched healthy controls, with the Sequenom MassArray system.
|
25846585 |
2015 |
|
rs2254546
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of the five haplotypes of the five SNPs (rs2736340, rs7812879, rs13277113, rs2618479 and rs2254546) was also significantly different between overall PM/DM, PM or DM patients and healthy controls.
|
25846585 |
2015 |
|
rs2292239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system.
|
26320593 |
2015 |
|
rs2492358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system.
|
26320593 |
2015 |
|
rs2736340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
|
rs2853676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system.
|
26320593 |
2015 |
|
rs7812879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
|
rs951005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This was the first study to demonstrate that the CCL21 gene SNP (rs951005) might confer genetic predisposition to PM patients or such patients with ILD in a Chinese Han population.
|
26320593 |
2015 |
|
rs2230926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated a strong allele association was observed in PM/DM and PM patients for rs2230926</span> (OR: 1.61, 95%CI: 1.20-2.16, P(c) = 7.5×10(-3); OR: 1.88, 95%CI: 1.30-2.74, P(c) = 4.0×10(-3), respectively) and rs5029939 (OR: 1.64, 95%CI: 1.21-2.21, P(c) = 6.0×10(-3); OR: 1.88, 95%CI: 1.28-2.76, P(c) = 5.5×10(-3), respectively).
|
25337792 |
2014 |
|
rs4728142
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs4728142 allele and genotype had significant association with PM/DM patients (P(c) = 0.026 and P(c) = 0.048, respectively).
|
25337792 |
2014 |
|
rs5029939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated a strong allele association was observed in PM/DM and PM patients for rs2230926 (OR: 1.61, 95%CI: 1.20-2.16, P(c) = 7.5×10(-3); OR: 1.88, 95%CI: 1.30-2.74, P(c) = 4.0×10(-3), respectively) and rs5029939 (OR: 1.64, 95%CI: 1.21-2.21, P(c) = 6.0×10(-3); OR: 1.88, 95%CI: 1.28-2.76, P(c) = 5.5×10(-3), respectively).
|
25337792 |
2014 |
|
rs1990760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, when comparing the AA and AG + GG genotypes at rs1990760, the AA genotype was significantly more frequent in PM patients with ILD than in healthy controls [odds ratio, 3.23 (95% confidence interval, 1.06-9.81); P = 0.04] or in PM patients without ILD [odds ratio, 5.40 (95% confidence interval, 1.37-21.26); P = 0.027].
|
20467774 |
2010 |