Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1229984
rs1229984
0.030 GeneticVariation BEFREE Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]). 21917409

2012

dbSNP: rs1229984
rs1229984
0.030 GeneticVariation BEFREE Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men. 24018899

2014

dbSNP: rs1229984
rs1229984
0.030 GeneticVariation BEFREE We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence. 24553426

2014

dbSNP: rs4964057
rs4964057
0.030 GeneticVariation BEFREE Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057). 22538398

2012

dbSNP: rs4964057
rs4964057
0.030 GeneticVariation BEFREE Concerning alcohol use, the current findings give support, but are preliminary to, the associations of ARNTL (BMAL1) rs6486120 with alcohol consumption, ARNTL2 rs7958822 and ARNTL2 rs4964057 with alcohol abuse, and PER1 rs3027172 and PER2 rs56013859 with alcohol dependence. 25677407

2015

dbSNP: rs4964057
rs4964057
0.030 GeneticVariation BEFREE ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013). 20554694

2010

dbSNP: rs7958822
rs7958822
0.030 GeneticVariation BEFREE Concerning alcohol use, the current findings give support, but are preliminary to, the associations of ARNTL (BMAL1) rs6486120 with alcohol consumption, ARNTL2 rs7958822 and ARNTL2 rs4964057 with alcohol abuse, and PER1 rs3027172 and PER2 rs56013859 with alcohol dependence. 25677407

2015

dbSNP: rs7958822
rs7958822
0.030 GeneticVariation BEFREE ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013). 20554694

2010

dbSNP: rs7958822
rs7958822
0.030 GeneticVariation BEFREE Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057). 22538398

2012

dbSNP: rs1800562
rs1800562
0.020 GeneticVariation BEFREE Unlike these rare instances, in white people, homozygotes for C282Y polymorphism in HFE are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, when these individuals abuse alcohol or from other unidentified modifying factors. 20542038

2010

dbSNP: rs1800562
rs1800562
0.020 GeneticVariation BEFREE In Caucasians, C282Y HFE homozygotes are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, due to alcohol abuse or concurrent genetic modifiers that are now being identified. 26164493

2015

dbSNP: rs1001179
rs1001179
CAT
0.010 GeneticVariation BEFREE Using an established PCR-RFLP method for genotyping, we examined the association of rs1001179 with glycated hemoglobin (HbA1c) and plasma lipids using univariate analyses with age, sex, body mass index (BMI), smoking, and alcohol abuse as covariates, in a group of dyslipidemic patients from northern Greece. 27704307

2017

dbSNP: rs1034936
rs1034936
0.010 GeneticVariation BEFREE Our findings suggest a role of rs1034936 CACNA1C gene variant in BD-AA group. 31634677

2020

dbSNP: rs12655166
rs12655166
0.010 GeneticVariation BEFREE Adjusting for multiple tests, one NR3C1 SNP (rs12655166) significantly moderated intervention effects on the developmental trajectories of alcohol abuse among AAs. 27817096

2018

dbSNP: rs13212041
rs13212041
0.010 GeneticVariation BEFREE Determination of platelet 5-HT concentration and genotyping of rs13212041 <i>HTR1B</i> gene polymorphism were performed in 613 alcohol-dependent patients, subdivided according to early/late onset (before/after 25 years of age) of alcohol abuse. 30774345

2019

dbSNP: rs17110747
rs17110747
0.010 GeneticVariation BEFREE More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE. 24491795

2014

dbSNP: rs17817449
rs17817449
FTO
0.010 GeneticVariation BEFREE We investigated whether a tagging variant (rs17817449) within the FTO gene is associated with alcohol intake, problem drinking and smoking behaviour. 31055022

2019

dbSNP: rs1799971
rs1799971
0.010 GeneticVariation BEFREE The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384). 23729673

2014

dbSNP: rs1799983
rs1799983
0.010 GeneticVariation BEFREE Genomic DNA from 103 patients with nontraumatic FHON (idiopathic in 50, steroid-induced in 29, and alcohol abuse in 24) and 103 control subjects matched for gender and age (3-year range) was analyzed for the 27-bp repeat polymorphism in intron 4 and Glu298Asp polymorphism in exon 7. 16779830

2006

dbSNP: rs2306073
rs2306073
0.010 GeneticVariation BEFREE Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057). 22538398

2012

dbSNP: rs2567608
rs2567608
0.010 GeneticVariation BEFREE None of following characteristics: current age, gender, term and kind of labor, 13 categories of childhood trauma, diet, alcohol drinking severity, age at alcohol drinking initiation, age at onset of problem drinking, cigarette smoking, and <i>SSTR4</i> rs2567608 was a significant predictor for <i>SSTR4</i> promoter region methylation. 29104801

2017

dbSNP: rs324420
rs324420
0.010 GeneticVariation BEFREE As this FAAH SNP has been reported to be associated with altered alcohol abuse, the present study used these genetic knock-in mice containing the human SNP C385A to determine the impact of variant FAAH gene on alcohol "binge" drinking in the drinking-in-the-dark (DID) model. 26857901

2016

dbSNP: rs348449
rs348449
0.010 GeneticVariation BEFREE Additionally, rs348449 is highly associated with problem drinking (allelic odds ratio [OR] 7.87, 95 per cent confidence interval [CI] 1.67-37.01) but due to the low minor allele frequency (0.01 and 0.07 in controls and problem drinkers, respectively), more samples are required to validate this observation. 19129088

2008

dbSNP: rs4570625
rs4570625
0.010 GeneticVariation BEFREE More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE. 24491795

2014

dbSNP: rs4680
rs4680
0.010 GeneticVariation BEFREE The current study found that COMT rs4680 was related to both dimensionally and categorically measured gambling and drinking problems. 24390676

2015