rs1229984
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
rs1229984
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.
|
24018899 |
2014 |
rs1229984
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.
|
24553426 |
2014 |
rs698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
rs348449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs348449 is highly associated with problem drinking (allelic odds ratio [OR] 7.87, 95 per cent confidence interval [CI] 1.67-37.01) but due to the low minor allele frequency (0.01 and 0.07 in controls and problem drinkers, respectively), more samples are required to validate this observation.
|
19129088 |
2008 |
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
rs4964057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
|
22538398 |
2012 |
rs4964057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Concerning alcohol use, the current findings give support, but are preliminary to, the associations of ARNTL (BMAL1) rs6486120 with alcohol consumption, ARNTL2 rs7958822 and ARNTL2 rs4964057 with alcohol abuse, and PER1 rs3027172 and PER2 rs56013859 with alcohol dependence.
|
25677407 |
2015 |
rs4964057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013).
|
20554694 |
2010 |
rs7958822
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Concerning alcohol use, the current findings give support, but are preliminary to, the associations of ARNTL (BMAL1) rs6486120 with alcohol consumption, ARNTL2 rs7958822 and ARNTL2 rs4964057 with alcohol abuse, and PER1 rs3027172 and PER2 rs56013859 with alcohol dependence.
|
25677407 |
2015 |
rs7958822
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013).
|
20554694 |
2010 |
rs7958822
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
|
22538398 |
2012 |
rs2306073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
|
22538398 |
2012 |
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse.
|
25510982 |
2014 |
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse.
|
25510982 |
2014 |
rs1034936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest a role of rs1034936 CACNA1C gene variant in BD-AA group.
|
31634677 |
2020 |
rs1001179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using an established PCR-RFLP method for genotyping, we examined the association of rs1001179 with glycated hemoglobin (HbA1c) and plasma lipids using univariate analyses with age, sex, body mass index (BMI), smoking, and alcohol abuse as covariates, in a group of dyslipidemic patients from northern Greece.
|
27704307 |
2017 |
rs53576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Oxytocin receptor gene variation rs53576 and alcohol abuse in a longitudinal population representative study.
|
27716573 |
2016 |
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study found that COMT rs4680 was related to both dimensionally and categorically measured gambling and drinking problems.
|
24390676 |
2015 |
rs324420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As this FAAH SNP has been reported to be associated with altered alcohol abuse, the present study used these genetic knock-in mice containing the human SNP C385A to determine the impact of variant FAAH gene on alcohol "binge" drinking in the drinking-in-the-dark (DID) model.
|
26857901 |
2016 |
rs17817449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether a tagging variant (rs17817449) within the FTO gene is associated with alcohol intake, problem drinking and smoking behaviour.
|
31055022 |
2019 |
rs1800562
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Unlike these rare instances, in white people, homozygotes for C282Y polymorphism in HFE are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, when these individuals abuse alcohol or from other unidentified modifying factors.
|
20542038 |
2010 |
rs1800562
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In Caucasians, C282Y HFE homozygotes are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, due to alcohol abuse or concurrent genetic modifiers that are now being identified.
|
26164493 |
2015 |
rs13212041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Determination of platelet 5-HT concentration and genotyping of rs13212041 <i>HTR1B</i> gene polymorphism were performed in 613 alcohol-dependent patients, subdivided according to early/late onset (before/after 25 years of age) of alcohol abuse.
|
30774345 |
2019 |
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genomic DNA from 103 patients with nontraumatic FHON (idiopathic in 50, steroid-induced in 29, and alcohol abuse in 24) and 103 control subjects matched for gender and age (3-year range) was analyzed for the 27-bp repeat polymorphism in intron 4 and Glu298Asp polymorphism in exon 7.
|
16779830 |
2006 |