This study examined the main and interaction effects of the <i>OXTR</i> rs53576 genotype in distinguishing four subgroups identified by symptom profiles of PTSD and depression symptoms using latent profile analysis.<b>Design:</b> A cross-sectional design with a gene-environment interaction approach was adopted in the current study.<b>Methods:</b> This study was a secondary data analysis conducted on a sample of 1196 adult earthquake survivors.