rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Previous studies suggested lipoprotein lipase (LPL) Ser447Ter and Asn291Ser polymorphisms were associated with the risk of ischemic heart disease, however, their effects on ischemic stroke were controversial.
|
21816453 |
2011 |
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Pairwise combinations of D9N with -219G > T in APOE and N291S and S447X in LPL significantly improved the prediction of IHD (P = 0.05 in women, P = 0.04 in men, P = 0.03 in men, respectively) beyond smoking, diabetes and hypertension, and identified subgroups of individuals (n = 6-94) with highly significant HRs of 1.92-4.35.
|
17006673 |
2007 |
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers.
|
10359734 |
1999 |
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease.
|
9120004 |
1997 |
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We previously showed that the common Asn291Ser substitution in lipoprotein lipase is associated with elevated plasma triglyceride levels and a 2-fold increase in the risk of ischemic heart disease in women but not men.
|
10821816 |
2000 |
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We have examined the risk of IHD in carriers of two common LPL variants, asparagine substitution for aspartic acid at residue 9 (D9N) and serine for asparagine at residue 291 (N291S) in 2708 middle-aged healthy European men, followed for over 6 years.
|
10704617 |
2000 |
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
One of these, Asn291Ser, was also found to be associated with increased ischemic heart disease in women.
|
11127970 |
2000 |
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease.
|
12208477 |
2002 |
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease.
|
18948423 |
2009 |
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease.
|
25927599 |
2015 |
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD).
|
26901385 |
2016 |
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G.
|
10720891 |
2000 |
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Three countries with elevated IHD risks from <i>MTHFR</i> C677T polymorphism with RR >2 included India, Turkey, and Tunisia.
|
29996520 |
2018 |
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
However, we cannot exclude a direct causal effect of MTHFR C677T genotype on IHD.
|
24458267 |
2014 |
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population.
|
12220440 |
2002 |
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease.
|
12417280 |
2002 |
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease.
|
25927599 |
2015 |
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G.
|
10720891 |
2000 |
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD).
|
26901385 |
2016 |
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease.
|
18948423 |
2009 |
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Heterozygous lipoprotein lipase deficiency due to the Gly188-->Glu substitution appears to increase plasma triglycerides and reduce HDL levels and may thereby predispose carriers to ischemic heart disease.
|
9323055 |
1997 |
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease.
|
12208477 |
2002 |
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers.
|
10359734 |
1999 |
rs1320702652
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease.
|
24431031 |
2014 |
rs1320702652
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Possession of the C34T mutation in AMP deaminase (AMPD1) gene has been shown to be associated with attenuation of the progression of heart failure and improved survival in ischemic heart disease.
|
16021915 |
2005 |