|
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease.
|
9120004 |
1997 |
|
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Heterozygous lipoprotein lipase deficiency due to the Gly188-->Glu substitution appears to increase plasma triglycerides and reduce HDL levels and may thereby predispose carriers to ischemic heart disease.
|
9323055 |
1997 |
|
rs12713559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterzygous carriers of the Arg3531Cys mutation in the general population did not have higher-than-normal plasma cholesterol levels or an increased risk of ischemic heart disease (odds ratio; 1.4; 95 percent confidence interval, 0.2 to 11; P=0.54).
|
9603795 |
1998 |
|
rs5742904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Arg3500Gln mutation in the apolipoprotein B gene, which is responsible for familial defective apolipoprotein B-100 and is present in approximately 1 in 1000 persons in Denmark, causes severe hypercholesterolemia and increases the risk of ischemic heart disease.
|
9603795 |
1998 |
|
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers.
|
10359734 |
1999 |
|
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers.
|
10359734 |
1999 |
|
rs1801177
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers.
|
10359734 |
1999 |
|
rs1801177
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results demonstrate that the Asp9Asn substitution is in linkage disequilibrium with the T(-93)-->G mutation and that the double-heterozygous carrier status is associated with elevated plasma triglycerides and an increased risk of IHD in men.
|
10364086 |
1999 |
|
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We have examined the risk of IHD in carriers of two common LPL variants, asparagine substitution for aspartic acid at residue 9 (D9N) and serine for asparagine at residue 291 (N291S) in 2708 middle-aged healthy European men, followed for over 6 years.
|
10704617 |
2000 |
|
rs1801177
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers.
|
10704617 |
2000 |
|
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G.
|
10720891 |
2000 |
|
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G.
|
10720891 |
2000 |
|
rs5882
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 9168 women and men from a general population and 946 women and men with ischemic heart disease (all white), we tested the hypothesis that the Ile405Val mutation in the cholesteryl ester transfer protein gene (CETP) affects HDL cholesterol levels and the risk of ischemic heart disease.
|
10779455 |
2000 |
|
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We previously showed that the common Asn291Ser substitution in lipoprotein lipase is associated with elevated plasma triglyceride levels and a 2-fold increase in the risk of ischemic heart disease in women but not men.
|
10821816 |
2000 |
|
rs1800777
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A373P/R451Q polymorphism in CETP is associated with decreases in HDL cholesterol of 0.12 to 0.36 mmol/L in women and 0.14 to 0.21 mmol/L in men and possibly with a paradoxical 36% decrease in the risk of ischemic heart disease in women.
|
11056092 |
2000 |
|
rs5880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A373P/R451Q polymorphism in CETP is associated with decreases in HDL cholesterol of 0.12 to 0.36 mmol/L in women and 0.14 to 0.21 mmol/L in men and possibly with a paradoxical 36% decrease in the risk of ischemic heart disease in women.
|
11056092 |
2000 |
|
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
One of these, Asn291Ser, was also found to be associated with increased ischemic heart disease in women.
|
11127970 |
2000 |
|
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease.
|
11352695 |
2001 |
|
rs4762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease.
|
11352695 |
2001 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Leu(10)-->Pro (codon 10) polymorphism in the TGF-beta1 gene is associated with end-stage heart failure caused by dilated CMP and not with IHD.
|
11557193 |
2001 |
|
rs1800206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association between the leucine 162 to valine (L162V) polymorphism and a G to C transversion in intron 7 of the PPARalpha gene and progression of atherosclerosis in the Lopid Coronary Angiography Trial (LOCAT), a trial examining the effect of gemfibrozil treatment on progression of atherosclerosis after bypass surgery and on risk of IHD in the second Northwick Park Heart Study (NPHS2), a prospective study of healthy middle-aged men in the United Kingdom.
|
11914252 |
2002 |
|
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease.
|
12208477 |
2002 |
|
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease.
|
12208477 |
2002 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population.
|
12220440 |
2002 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease.
|
12417280 |
2002 |