Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE Previous studies suggested lipoprotein lipase (LPL) Ser447Ter and Asn291Ser polymorphisms were associated with the risk of ischemic heart disease, however, their effects on ischemic stroke were controversial. 21816453

2011

dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE Pairwise combinations of D9N with -219G > T in APOE and N291S and S447X in LPL significantly improved the prediction of IHD (P = 0.05 in women, P = 0.04 in men, P = 0.03 in men, respectively) beyond smoking, diabetes and hypertension, and identified subgroups of individuals (n = 6-94) with highly significant HRs of 1.92-4.35. 17006673

2007

dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers. 10359734

1999

dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease. 9120004

1997

dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE We previously showed that the common Asn291Ser substitution in lipoprotein lipase is associated with elevated plasma triglyceride levels and a 2-fold increase in the risk of ischemic heart disease in women but not men. 10821816

2000

dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE We have examined the risk of IHD in carriers of two common LPL variants, asparagine substitution for aspartic acid at residue 9 (D9N) and serine for asparagine at residue 291 (N291S) in 2708 middle-aged healthy European men, followed for over 6 years. 10704617

2000

dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE One of these, Asn291Ser, was also found to be associated with increased ischemic heart disease in women. 11127970

2000

dbSNP: rs268
rs268
LPL
0.080 GeneticVariation BEFREE The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease. 12208477

2002

dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease. 18948423

2009

dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease. 25927599

2015

dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD). 26901385

2016

dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G. 10720891

2000

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE Three countries with elevated IHD risks from <i>MTHFR</i> C677T polymorphism with RR >2 included India, Turkey, and Tunisia. 29996520

2018

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE However, we cannot exclude a direct causal effect of MTHFR C677T genotype on IHD. 24458267

2014

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population. 12220440

2002

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease. 12417280

2002

dbSNP: rs1799895
rs1799895
0.040 GeneticVariation BEFREE Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease. 25927599

2015

dbSNP: rs1799895
rs1799895
0.040 GeneticVariation BEFREE Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G. 10720891

2000

dbSNP: rs1799895
rs1799895
0.040 GeneticVariation BEFREE Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD). 26901385

2016

dbSNP: rs1799895
rs1799895
0.040 GeneticVariation BEFREE An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease. 18948423

2009

dbSNP: rs118204057
rs118204057
LPL
0.030 GeneticVariation BEFREE Heterozygous lipoprotein lipase deficiency due to the Gly188-->Glu substitution appears to increase plasma triglycerides and reduce HDL levels and may thereby predispose carriers to ischemic heart disease. 9323055

1997

dbSNP: rs118204057
rs118204057
LPL
0.030 GeneticVariation BEFREE The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease. 12208477

2002

dbSNP: rs118204057
rs118204057
LPL
0.030 GeneticVariation BEFREE Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers. 10359734

1999

dbSNP: rs1320702652
rs1320702652
0.030 GeneticVariation BEFREE Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease. 24431031

2014

dbSNP: rs1320702652
rs1320702652
0.030 GeneticVariation BEFREE Possession of the C34T mutation in AMP deaminase (AMPD1) gene has been shown to be associated with attenuation of the progression of heart failure and improved survival in ischemic heart disease. 16021915

2005