rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease.
|
18948423 |
2009 |
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease.
|
25927599 |
2015 |
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD).
|
26901385 |
2016 |
rs1022113606
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G.
|
10720891 |
2000 |
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities.
|
25413568 |
2015 |
rs1042579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several published studies have shown that the Ala455Val thrombomodulin polymorphism is associated with ischemic heart disease, but none has examined the association with stroke.
|
15574195 |
2004 |
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, a multivariate logistic regression analysis in which age, gender, body mass index (BMI), and ischemic heart disease were included as independent variables indicated that Ser326Cys could be an independent factor affecting tooth loss (OR, 3.191; 95%CI, 1.174-8.672).
|
16538639 |
2006 |
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
rs10757278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-allele of both SNPs predicted incident stroke in crude additive models [rs2383207 hazard ratios = 1.25 (95% CI = 1.02-1.53), P = 0.04 and rs10757278 hazard ratios = 1.34 (95% CI = 1.09-1.65), P = 0.006], as well as after adjustment for classical cardiovascular risk factors and after additional adjustment for prevalent and incident coronary events, atrial fibrillation, ischemic heart disease and congestive heart failure.
|
19293724 |
2009 |
rs10761741
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
rs10903323
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MSRA rs10903323 gene polymorphism may be implicated in the increased risk to develop CV events, in particular ischaemic heart disease, observed in RA patients.
|
22657383 |
2012 |
rs11053646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein.
|
12646194 |
2003 |
rs11234027
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
rs1137101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In subanalyses according to CHF etiology the LEPR Gln223Arg showed an independent prediction role for NYHA IV in IHD patients (P = 0.0001, OR = 2.50, 95% CI = 1.69-3.82) and both for NYHA IV(P = 0.007, OR = 2.04, 95% CI = 1.20-3.84) and LVEF (P = 0.004, OR = 11.87, 95% CI = 2.08-55.6) in DCMP patients.
|
19337797 |
2009 |
rs1144507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD).
|
16289551 |
2006 |
rs114694170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
rs11549465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia.
|
21945026 |
2011 |
rs11591147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We determined the association of R46L genotype with LDL-C, risk of IHD, myocardial infarction (MI), and mortality in the prospective CCHS (Copenhagen City Heart Study) (n = 10,032) and validated the results in: 1) the cross-sectional CGPS (Copenhagen General Population Study) (n = 26,013); and 2) the case-control CIHDS (Copenhagen Ischemic Heart Disease Study) (n = 9,654).
|
20579540 |
2010 |
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Heterozygous lipoprotein lipase deficiency due to the Gly188-->Glu substitution appears to increase plasma triglycerides and reduce HDL levels and may thereby predispose carriers to ischemic heart disease.
|
9323055 |
1997 |
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease.
|
12208477 |
2002 |
rs118204057
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers.
|
10359734 |
1999 |
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Three countries with elevated IHD risks from <i>MTHFR</i> C677T polymorphism with RR >2 included India, Turkey, and Tunisia.
|
29996520 |
2018 |
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
However, we cannot exclude a direct causal effect of MTHFR C677T genotype on IHD.
|
24458267 |
2014 |
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population.
|
12220440 |
2002 |