Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease. 18948423

2009

dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease. 25927599

2015

dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD). 26901385

2016

dbSNP: rs1022113606
rs1022113606
0.040 GeneticVariation BEFREE Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G. 10720891

2000

dbSNP: rs1024611
rs1024611
0.010 GeneticVariation BEFREE Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities. 25413568

2015

dbSNP: rs1042579
rs1042579
0.010 GeneticVariation BEFREE Several published studies have shown that the Ala455Val thrombomodulin polymorphism is associated with ischemic heart disease, but none has examined the association with stroke. 15574195

2004

dbSNP: rs1045642
rs1045642
0.010 GeneticVariation BEFREE ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis. 25118983

2014

dbSNP: rs1052133
rs1052133
0.010 GeneticVariation BEFREE In addition, a multivariate logistic regression analysis in which age, gender, body mass index (BMI), and ischemic heart disease were included as independent variables indicated that Ser326Cys could be an independent factor affecting tooth loss (OR, 3.191; 95%CI, 1.174-8.672). 16538639

2006

dbSNP: rs10741657
rs10741657
0.010 GeneticVariation BEFREE Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011. 25981321

2015

dbSNP: rs10757278
rs10757278
0.010 GeneticVariation BEFREE The G-allele of both SNPs predicted incident stroke in crude additive models [rs2383207 hazard ratios = 1.25 (95% CI = 1.02-1.53), P = 0.04 and rs10757278 hazard ratios = 1.34 (95% CI = 1.09-1.65), P = 0.006], as well as after adjustment for classical cardiovascular risk factors and after additional adjustment for prevalent and incident coronary events, atrial fibrillation, ischemic heart disease and congestive heart failure. 19293724

2009

dbSNP: rs10761741
rs10761741
0.010 GeneticVariation BEFREE Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting. 28765276

2017

dbSNP: rs10903323
rs10903323
0.010 GeneticVariation BEFREE The MSRA rs10903323 gene polymorphism may be implicated in the increased risk to develop CV events, in particular ischaemic heart disease, observed in RA patients. 22657383

2012

dbSNP: rs11053646
rs11053646
0.010 GeneticVariation BEFREE We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein. 12646194

2003

dbSNP: rs11234027
rs11234027
0.010 GeneticVariation BEFREE Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011. 25981321

2015

dbSNP: rs1137101
rs1137101
0.010 GeneticVariation BEFREE In subanalyses according to CHF etiology the LEPR Gln223Arg showed an independent prediction role for NYHA IV in IHD patients (P = 0.0001, OR = 2.50, 95% CI = 1.69-3.82) and both for NYHA IV(P = 0.007, OR = 2.04, 95% CI = 1.20-3.84) and LVEF (P = 0.004, OR = 11.87, 95% CI = 2.08-55.6) in DCMP patients. 19337797

2009

dbSNP: rs1144507
rs1144507
0.010 GeneticVariation BEFREE We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD). 16289551

2006

dbSNP: rs114694170
rs114694170
0.010 GeneticVariation BEFREE Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting. 28765276

2017

dbSNP: rs11549465
rs11549465
0.010 GeneticVariation BEFREE The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia. 21945026

2011

dbSNP: rs11591147
rs11591147
0.010 GeneticVariation BEFREE We determined the association of R46L genotype with LDL-C, risk of IHD, myocardial infarction (MI), and mortality in the prospective CCHS (Copenhagen City Heart Study) (n = 10,032) and validated the results in: 1) the cross-sectional CGPS (Copenhagen General Population Study) (n = 26,013); and 2) the case-control CIHDS (Copenhagen Ischemic Heart Disease Study) (n = 9,654). 20579540

2010

dbSNP: rs118204057
rs118204057
LPL
0.030 GeneticVariation BEFREE Heterozygous lipoprotein lipase deficiency due to the Gly188-->Glu substitution appears to increase plasma triglycerides and reduce HDL levels and may thereby predispose carriers to ischemic heart disease. 9323055

1997

dbSNP: rs118204057
rs118204057
LPL
0.030 GeneticVariation BEFREE The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease. 12208477

2002

dbSNP: rs118204057
rs118204057
LPL
0.030 GeneticVariation BEFREE Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers. 10359734

1999

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE Three countries with elevated IHD risks from <i>MTHFR</i> C677T polymorphism with RR >2 included India, Turkey, and Tunisia. 29996520

2018

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE However, we cannot exclude a direct causal effect of MTHFR C677T genotype on IHD. 24458267

2014

dbSNP: rs1217691063
rs1217691063
0.040 GeneticVariation BEFREE Lack of association between methylenetetrahydrofolate reductase (MTHFR) C677T and ischaemic heart disease (IHD): family-based association study in a Spanish population. 12220440

2002